Alternative Titleチベット高地民の女性における特異なヘモグロビン動態
Periodical titleTropical Medicine and Health
Degree GrantorNagasaki University (長崎大学)
Note (General)Background: Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas. Hb concentrations generally decrease with increasing age. However, in the highlands, chronic altitude sickness is known to occur in the elderly population. To investigate how aging in a hypoxic environment affects Hb levels in Tibetan highlanders, we focused on the Mustang people, who live above 3500 m. We tried to clarify the pure relationship between aging and Hb levels in a hypoxic environment.Results: We found that the Hb concentration increased with increasing age in females but not in males. Multivariate analysis showed that age, pulse pressure, the poverty index, and vascular diameter were strongly correlated with the Hb concentration.Conclusions: We found unique Hb dynamics among female Tibetan highlanders. As seen in these Hb dynamics, there may be sex-based differences in the adaptive mechanism in Tibetan highlanders.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1343号 学位授与年月日:令和3年3月22日
Author: Hiroaki Arima, Masayuki Nakano, Sweta Koirala, Hiromu Ito, Basu Dev Pandey, Kishor Pandey, Takayuki Wada & Taro Yamamoto
Citation: Tropical Medicine and Health, 49, art.no.2; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2021-03-22)
機関リポジトリ記載の権利情報: © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2021-06-07T02:06:26+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション