The drainage mechanism of beta amyloid (Aβ) from the intra-arterial perivascular space by LRP1 receptors of the blood brain barrier endothelial cells

• 資料種別: 記事
• タイトル: The drainage mechanism of beta amyloid (Aβ) from the intra-arterial perivascular space by LRP1 receptors of the blood brain barrier endothelial cells
• 著者・編者: Nikola Barić
• 出版事項: 日本 : 糖化ストレス研究会
• 出版年月日等: 2021-03-31
• 出版年（W3CDTF）: 2021-03-31
• タイトル（掲載誌）: Glycative stress research
• 巻号年月日等（掲載誌）: 8(1)
• 掲載巻: 8(1)
• ISSN（掲載誌）: 2188-3610
• ISSN-L（掲載誌）: 2188-3610
• 本文の言語コード: eng
• DOI: 10.24659/gsr.8.1_8; https://doi.org/10.24659/gsr.8.1_8
• 国立国会図書館永続的識別子: info:ndljp/pid/11703335; https://dl.ndl.go.jp/pid/11703335
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2021-07-14T21:40:34+09:00
• 保存日（W3CDTF）: 2021-05-23
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://www.toukastress.jp/webj/
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/11703333; https://dl.ndl.go.jp/pid/11703333
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: A number of recent research studies related to the significantly important intra-arterial perivascular drainage pathway indicates its crucial role in maintaining the optimal brain homeostasis. Driven by the pulsatile vasomotion forces, this drainage carries and cleans a whole complex of brain metabolism waste products, especially beta amyloid (Aβ). In the case of a markedly increased intracerebral concentration, especially of toxic Aβ, or alterated vasomotion, the drainage pathway undergoes a burdening in the flow, its collapse, and sedimentation of waste particles, among them Aβ aggregates in particular. In addition to the Aβ elimination through this drainage pathway that ends in the neck paracarotide lymph nodes, the drainage from this space also takes place by endothelial receptors and the transcytosis mechanism through the cytoplasm of endothel cells into the capillary blood. The aim of this study is to present a detailed explanation of these drainages, with the special analysis of LRP1 receptor and its functions in these events.
• DOI: 10.24659/gsr.8.1_8
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: A number of recent research studies related to the significantly important intra-arterial perivascular drainage pathway indicates its crucial role in maintaining the optimal brain homeostasis. Driven by the pulsatile vasomotion forces, this drainage carries and cleans a whole complex of brain metabolism waste products, especially beta amyloid (Aβ). In the case of a markedly increased intracerebral concentration, especially of toxic Aβ, or alterated vasomotion, the drainage pathway undergoes a burdening in the flow, its collapse, and sedimentation of waste particles, among them Aβ aggregates in particular. In addition to the Aβ elimination through this drainage pathway that ends in the neck paracarotide lymph nodes, the drainage from this space also takes place by endothelial receptors and the transcytosis mechanism through the cytoplasm of endothel cells into the capillary blood. The aim of this study is to present a detailed explanation of these drainages, with the special analysis of LRP1 receptor and its functions in these events.
• DOI: 10.24659/gsr.8.1_8; https://doi.org/10.24659/gsr.8.1_8
• 関連情報（URI）: http://id.ndl.go.jp/bib/032133608; https://ndlsearch.ndl.go.jp/books/R000000004-I032133608; http://id.ndl.go.jp/digimeta/11703335; https://dl.ndl.go.jp/pid/11703335; https://search.jamas.or.jp/link/ui/2022048920
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• 書誌ID（NDLBibID）: 032133608; http://id.ndl.go.jp/bib/032133608; 11703335; http://id.ndl.go.jp/bib/11703335
• NII論文ID: 130008046234