The drainage mechanism of beta amyloid (Aβ) from the intra-arterial perivascular space by LRP1 receptors of the blood brain barrier endothelial cells
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DOI[10.24659/gsr.8.1_8]to the data of the same series
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- Material Type
- 記事
- Author/Editor
- Nikola Barić
- Publication, Distribution, etc.
- Publication Date
- 2021-03-31
- Publication Date (W3CDTF)
- 2021-03-31
- Periodical title
- Glycative stress research
- No. or year of volume/issue
- 8(1)
- Volume
- 8(1)
- ISSN (Periodical Title)
- 2188-3610
- ISSN-L (Periodical Title)
- 2188-3610
- Text Language Code
- eng
- DOI
- 10.24659/gsr.8.1_8
- Persistent ID (NDL)
- info:ndljp/pid/11703335
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Acquisition Basis
- オンライン資料収集制度
- Date Accepted (W3CDTF)
- 2021-07-14T21:40:34+09:00
- Date Captured (W3CDTF)
- 2021-05-23
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Periodical Title (Persistent ID (NDL))
- info:ndljp/pid/11703333
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Summary, etc.
- A number of recent research studies related to the significantly important intra-arterial perivascular drainage pathway indicates its crucial role in maintaining the optimal brain homeostasis. Driven by the pulsatile vasomotion forces, this drainage carries and cleans a whole complex of brain metabolism waste products, especially beta amyloid (Aβ). In the case of a markedly increased intracerebral concentration, especially of toxic Aβ, or alterated vasomotion, the drainage pathway undergoes a burdening in the flow, its collapse, and sedimentation of waste particles, among them Aβ aggregates in particular. In addition to the Aβ elimination through this drainage pathway that ends in the neck paracarotide lymph nodes, the drainage from this space also takes place by endothelial receptors and the transcytosis mechanism through the cytoplasm of endothel cells into the capillary blood. The aim of this study is to present a detailed explanation of these drainages, with the special analysis of LRP1 receptor and its functions in these events.
- DOI
- 10.24659/gsr.8.1_8
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- A number of recent research studies related to the significantly important intra-arterial perivascular drainage pathway indicates its crucial role in maintaining the optimal brain homeostasis. Driven by the pulsatile vasomotion forces, this drainage carries and cleans a whole complex of brain metabolism waste products, especially beta amyloid (Aβ). In the case of a markedly increased intracerebral concentration, especially of toxic Aβ, or alterated vasomotion, the drainage pathway undergoes a burdening in the flow, its collapse, and sedimentation of waste particles, among them Aβ aggregates in particular. In addition to the Aβ elimination through this drainage pathway that ends in the neck paracarotide lymph nodes, the drainage from this space also takes place by endothelial receptors and the transcytosis mechanism through the cytoplasm of endothel cells into the capillary blood. The aim of this study is to present a detailed explanation of these drainages, with the special analysis of LRP1 receptor and its functions in these events.
- DOI
- 10.24659/gsr.8.1_8
- Related Material (URI)
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベース雑誌記事索引データベースCiNii Articles
- Bibliographic ID (NDL)
- 03213360811703335
- NAID
- 130008046234