Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation

• 資料種別: 博士論文
• ISSN: 0912-0009
• タイトル: Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation
• 巻次・部編番号: 69 2
• 著者・編者: Nakamoto, Akiko; Hirabayashi, Yuwa; Anzaki, Chieri; Nakamoto, Mariko; Shuto, Emi; Sakai, Tohru
• 著者標目: Nakamoto, Akiko; Hirabayashi, Yuwa; Anzaki, Chieri; Nakamoto, Mariko; Shuto, Emi; Sakai, Tohru
• 出版事項: Society for Free Radical Research Japan
• 出版年月日等: 2021-09-01
• 出版年（W3CDTF）: 2021-09-01
• 並列タイトル等: ノビレチンは17型ヘルパーT細胞の分化調節により、実験的自己免疫性脳脊髄炎の発症を抑制する
• タイトル（掲載誌）: Journal of Clinical Biochemistry and Nutrition
• 授与機関名: 徳島大学
• 授与年月日: 2021-07-29
• 授与年月日（W3CDTF）: 2021-07-29
• 報告番号: 乙第2117号
• 学位: 博士（栄養学）
• 博論授与番号: 乙第2117号
• 本文の言語コード: eng
• 件名標目: experimental autoimmune encephalomyelitis; nobiletin; polymethoxyflavonoid; Th17 differentiation; IL-17A; polymethoxyflavone
• 対象利用者: 一般
• 一般注記: Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation in vitro. Admin­istration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, in vitro analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.
• DOI: info:doi/10.3164/jcbn.20-178; https://doi.org/info:doi/10.3164/jcbn.20-178
• 国立国会図書館永続的識別子: info:ndljp/pid/11720035; https://dl.ndl.go.jp/pid/11720035
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-09-06T03:11:00+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/116141
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp