Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation

Persistent ID (NDL): info:ndljp/pid/11720035

Material type: 博士論文

Author: Nakamoto, Akikoほか

Publisher: Society for Free Radical Research Japan

Publication date: 2021-09-01

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（栄養学）

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Note (General)：: Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polym...

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Material Type: 博士論文
ISSN: 0912-0009
Title: Nobiletin suppresses the development of experimental autoimmune encephalomyelitis mediated by modulation of T helper 17 cell differentiation
Volume: 69 2
Author/Editor: Nakamoto, Akiko
Hirabayashi, Yuwa
Anzaki, Chieri
Nakamoto, Mariko
Shuto, Emi
Sakai, Tohru
Author Heading: Nakamoto, Akiko
Hirabayashi, Yuwa
Anzaki, Chieri
Nakamoto, Mariko
Shuto, Emi
Sakai, Tohru
Publication, Distribution, etc.: Society for Free Radical Research Japan
Publication Date: 2021-09-01
Publication Date (W3CDTF): 2021-09-01
Alternative Title: ノビレチンは17型ヘルパーT細胞の分化調節により、実験的自己免疫性脳脊髄炎の発症を抑制する
Periodical title: Journal of Clinical Biochemistry and Nutrition
Degree grantor/type: 徳島大学
Date Granted: 2021-07-29
Date Granted (W3CDTF): 2021-07-29
Dissertation Number: 乙第2117号
Degree Type: 博士（栄養学）
Conferring No. (Dissertation): 乙第2117号
Text Language Code: eng
Subject Heading: experimental autoimmune encephalomyelitis
nobiletin
polymethoxyflavonoid
Th17 differentiation
IL-17A
polymethoxyflavone
Target Audience: 一般
Note (General): Multiple sclerosis is an organ-specific autoimmune disease that targets the myelin antigen in the central nervous system. Nobiletin is a dietary polymethoxylated flavonoid found in citrus fruits. In this study, we investigated how nobiletin affects the disease state and immune responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis mice. Nobiletin was administered orally from 14 days before immunization until the end of the experiment, and clinical scores were determined. The production levels of interleukin-17A and interferon-γ were measured in a culture supernatant of splenocytes stimulated with myelin oligodendrocyte glycoprotein. In addition, flow cytometric analysis was performed to examine the effect of nobiletin on T cell differentiation in vitro. Administration of nobiletin significantly decreased the clinical score and interleukin-17A production in splenocytes. Furthermore, in vitro analysis showed that nobiletin significantly suppressed Th17 cell differentiation and interleukin-17A production in a dose-dependent manner. The results suggest that nobiletin attenuates experimental autoimmune encephalomyelitis severity through modulation of Th17 cell differentiation.
DOI: info:doi/10.3164/jcbn.20-178
https://doi.org/info:doi/10.3164/jcbn.20-178
Persistent ID (NDL): info:ndljp/pid/11720035
https://dl.ndl.go.jp/pid/11720035
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-09-06T03:11:00+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116141
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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