Semiquantitative assessment of fluorodeoxyglucose uptake in primary tumours on dynamic PET/computed tomography for lymph node metastasis evaluation in patients with lung cancer : a prospective study

• 資料種別: 博士論文
• ISSN: 0143-3636
• タイトル: Semiquantitative assessment of fluorodeoxyglucose uptake in primary tumours on dynamic PET/computed tomography for lymph node metastasis evaluation in patients with lung cancer : a prospective study
• 巻次・部編番号: 41 11
• 著者・編者: Yamanaka, Moriaki; Shinya, Takayoshi; Otomi, Yoichi; Kubo, Michiko; Arai, Yuta; Toba, Hiroaki; Bando, Yoshimi; Otsuka, Hideki; Harada, Masafumi
• 著者標目: Yamanaka, Moriaki; Shinya, Takayoshi; Otomi, Yoichi; Kubo, Michiko; Arai, Yuta; Toba, Hiroaki; Bando, Yoshimi; Otsuka, Hideki; Harada, Masafumi
• 出版事項: Wolters Kluwer Health, Inc.|British Nuclear Medicine Society
• 出版年月日等: 2020-11-01
• 出版年（W3CDTF）: 2020-11-01
• 並列タイトル等: 肺癌患者におけるリンパ節転移の評価に関するdynamic PET/CTの有用性の前向き検討; Semiquantitative assessment of FDG uptake in primary tumours
• タイトル（掲載誌）: Nuclear Medicine Communications
• 授与機関名: 徳島大学
• 授与年月日: 2021-03-23
• 授与年月日（W3CDTF）: 2021-03-23
• 報告番号: 甲第3495号
• 学位: 博士（医学）
• 博論授与番号: 甲第3495号
• 本文の言語コード: eng
• 件名標目: fluorodeoxyglucose F18; PET-computed tomography; lung cancer; lymphatic metastasis; positron emission tomography computed tomography
• 対象利用者: 一般
• 一般注記: Objective: To semiquantitatively estimate fluorine-18-fluorodeoxyglucose (FDG) uptake in primary lung cancer cells using dynamic and dual-time-point (DTP) positron emission tomography/computed tomography (PET/CT) to obtain a diagnostic index for lymph node (LN) metastasis.Methods: Forty-five patients with lung cancer underwent dynamic and DTP PET/CT examinations. All primary lesions and LN metastases were evaluated pathologically. At each time phase, we assessed the maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of the primary tumours. We investigated the relationship between semiquantitative index and the presence of LN metastasis for each case and for all cases satisfying indications for segmentectomy. In cases with LN metastasis, we assessed the SUVmax of pathologically proven metastatic LNs and non-metastatic LNs in each dynamic phase for evaluating temporal change.Results: Among 45 patients, 15 had 17 LN metastasis. SUVmax, MTV, and TLG of primary tumours at each time phase were significantly associated with LN metastasis (p < 0.05). In receiver operating characteristic analysis, dynamic second and third phases showed high diagnostic ability for LN metastasis. The temporal change in SUVmax in the dynamic phase between primary tumours and metastatic LNs were significantly different (p = 0.065). The temporal change in SUVmax was significantly lower in non-metastatic LNs than in primary tumours and metastatic LNs (p < 0.0001).Conclusions: Semiquantitative assessment of FDG uptake in dynamic second and third phases and the assessment of temporal changes in SUVmax on dynamic PET/CT scans were important predictors in diagnosing LN metastasis.
• DOI: info:doi/10.1097/MNM.0000000000001271; https://doi.org/info:doi/10.1097/MNM.0000000000001271
• 国立国会図書館永続的識別子: info:ndljp/pid/11864784; https://dl.ndl.go.jp/pid/11864784
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2021-11-08T14:10:24+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/116049
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp