Semiquantitative assessment of fluorodeoxyglucose uptake in primary tumours on dynamic PET/computed tomography for lymph node metastasis evaluation in patients with lung cancer : a prospective study

• Material Type: 博士論文
• ISSN: 0143-3636
• Title: Semiquantitative assessment of fluorodeoxyglucose uptake in primary tumours on dynamic PET/computed tomography for lymph node metastasis evaluation in patients with lung cancer : a prospective study
• Volume: 41 11
• Author/Editor: Yamanaka, Moriaki; Shinya, Takayoshi; Otomi, Yoichi; Kubo, Michiko; Arai, Yuta; Toba, Hiroaki; Bando, Yoshimi; Otsuka, Hideki; Harada, Masafumi
• Author Heading: Yamanaka, Moriaki; Shinya, Takayoshi; Otomi, Yoichi; Kubo, Michiko; Arai, Yuta; Toba, Hiroaki; Bando, Yoshimi; Otsuka, Hideki; Harada, Masafumi
• Publication, Distribution, etc.: Wolters Kluwer Health, Inc.|British Nuclear Medicine Society
• Publication Date: 2020-11-01
• Publication Date (W3CDTF): 2020-11-01
• Alternative Title: 肺癌患者におけるリンパ節転移の評価に関するdynamic PET/CTの有用性の前向き検討; Semiquantitative assessment of FDG uptake in primary tumours
• Periodical title: Nuclear Medicine Communications
• Degree grantor/type: 徳島大学
• Date Granted: 2021-03-23
• Date Granted (W3CDTF): 2021-03-23
• Dissertation Number: 甲第3495号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3495号
• Text Language Code: eng
• Subject Heading: fluorodeoxyglucose F18; PET-computed tomography; lung cancer; lymphatic metastasis; positron emission tomography computed tomography
• Target Audience: 一般
• Note (General): Objective: To semiquantitatively estimate fluorine-18-fluorodeoxyglucose (FDG) uptake in primary lung cancer cells using dynamic and dual-time-point (DTP) positron emission tomography/computed tomography (PET/CT) to obtain a diagnostic index for lymph node (LN) metastasis.Methods: Forty-five patients with lung cancer underwent dynamic and DTP PET/CT examinations. All primary lesions and LN metastases were evaluated pathologically. At each time phase, we assessed the maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) of the primary tumours. We investigated the relationship between semiquantitative index and the presence of LN metastasis for each case and for all cases satisfying indications for segmentectomy. In cases with LN metastasis, we assessed the SUVmax of pathologically proven metastatic LNs and non-metastatic LNs in each dynamic phase for evaluating temporal change.Results: Among 45 patients, 15 had 17 LN metastasis. SUVmax, MTV, and TLG of primary tumours at each time phase were significantly associated with LN metastasis (p < 0.05). In receiver operating characteristic analysis, dynamic second and third phases showed high diagnostic ability for LN metastasis. The temporal change in SUVmax in the dynamic phase between primary tumours and metastatic LNs were significantly different (p = 0.065). The temporal change in SUVmax was significantly lower in non-metastatic LNs than in primary tumours and metastatic LNs (p < 0.0001).Conclusions: Semiquantitative assessment of FDG uptake in dynamic second and third phases and the assessment of temporal changes in SUVmax on dynamic PET/CT scans were important predictors in diagnosing LN metastasis.
• DOI: info:doi/10.1097/MNM.0000000000001271; https://doi.org/info:doi/10.1097/MNM.0000000000001271
• Persistent ID (NDL): info:ndljp/pid/11864784; https://dl.ndl.go.jp/pid/11864784
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-11-08T14:10:24+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116049
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp