並列タイトル等CD49dは、Plasmodium chabaudi感染におけるTh1とTfh様抗原特異的CD4+ T細胞の マーカーである。
授与機関名Nagasaki University (長崎大学)
一般注記Upon activation, specific CD4+ T cells up-regulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4+ T cells. However, using T-cell receptor transgenic mice specific for a Plasmodium antigen, termed PbT-II, we found that activated CD4+ T cells develop not only to CD11ahiCD49dhi cells, but also to CD11ahiCD49dlo cells during acute Plasmodium infection. CD49dhi PbT-II cells, localized in the red pulp of spleens, expressed transcription factor T-bet and produced IFN-γ, indicating that they were type 1 helper T (Th1)-type cells. In contrast, CD49dlo PbT-II cells resided in the white pulp/marginal zones and were a heterogeneous population, with approximately half of them expressing CXCR5 and a third expressing Bcl-6, a master regulator of follicular helper T (Tfh) cells. In adoptive transfer experiments, both CD49dhi and CD49dlo PbT-II cells differentiated into CD49dhi Th1-type cells after stimulation with antigen-pulsed dendritic cells, while CD49dhi and CD49dlo phenotypes were generally maintained in mice infected with Plasmodium chabaudi. These results suggest that CD49d is expressed on Th1-type Plasmodium-specific CD4+ T cells, which are localized in the red pulp of the spleen, and can be used as a marker of antigen-specific Th1 CD4+ T cells, rather than that of all pathogen-specific CD4+ T cells.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1354号 学位授与年月日:令和3年6月2日
Author: Jiun-Yu Jian, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Mana Miyakoda, Daisuke Kimura, Kazumi Kimura, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R Heath, Katsuyuki Yui
Citation: International Immunology, 33(8), pp. 409–422; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02)
http://hdl.handle.net/10069/00040837
DOIinfo:doi/10.1093/intimm/dxab020
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