CD49d marks Th1 and Tfh-like antigen-specific CD4+ T cells during Plasmodium chabaudi infection

• Material Type: 博士論文
• ISSN: 1460-2377
• Title: CD49d marks Th1 and Tfh-like antigen-specific CD4+ T cells during Plasmodium chabaudi infection
• Volume: 33 8
• Author/Editor: 簡, 君宇
• Author Heading: 簡, 君宇
• Publication, Distribution, etc.: Oxford University Press
• Publication Date: 2021-06-02
• Publication Date (W3CDTF): 2021-06-02
• Alternative Title: CD49dは、Plasmodium chabaudi感染におけるTh1とTfh様抗原特異的CD4+ T細胞の マーカーである。
• Periodical title: International Immunology
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2021-06-02
• Date Granted (W3CDTF): 2021-06-02
• Dissertation Number: 甲医歯薬第1354号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1354号
• Text Language Code: eng
• Subject Heading: integrin; malaria
• Target Audience: 一般
• Note (General): Upon activation, specific CD4+ T cells up-regulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4+ T cells. However, using T-cell receptor transgenic mice specific for a Plasmodium antigen, termed PbT-II, we found that activated CD4+ T cells develop not only to CD11ahiCD49dhi cells, but also to CD11ahiCD49dlo cells during acute Plasmodium infection. CD49dhi PbT-II cells, localized in the red pulp of spleens, expressed transcription factor T-bet and produced IFN-γ, indicating that they were type 1 helper T (Th1)-type cells. In contrast, CD49dlo PbT-II cells resided in the white pulp/marginal zones and were a heterogeneous population, with approximately half of them expressing CXCR5 and a third expressing Bcl-6, a master regulator of follicular helper T (Tfh) cells. In adoptive transfer experiments, both CD49dhi and CD49dlo PbT-II cells differentiated into CD49dhi Th1-type cells after stimulation with antigen-pulsed dendritic cells, while CD49dhi and CD49dlo phenotypes were generally maintained in mice infected with Plasmodium chabaudi. These results suggest that CD49d is expressed on Th1-type Plasmodium-specific CD4+ T cells, which are localized in the red pulp of the spleen, and can be used as a marker of antigen-specific Th1 CD4+ T cells, rather than that of all pathogen-specific CD4+ T cells.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1354号 学位授与年月日:令和3年6月2日; Author: Jiun-Yu Jian, Shin-Ichi Inoue, Ganchimeg Bayarsaikhan, Mana Miyakoda, Daisuke Kimura, Kazumi Kimura, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R Heath, Katsuyuki Yui; Citation: International Immunology, 33(8), pp. 409–422; 2021; identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02); http://hdl.handle.net/10069/00040837
• DOI: info:doi/10.1093/intimm/dxab020; https://doi.org/info:doi/10.1093/intimm/dxab020
• Persistent ID (NDL): info:ndljp/pid/11976730; https://dl.ndl.go.jp/pid/11976730
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
• Date Created (W3CDTF): 2021-12-28
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/00040837
• Periodical Title (URI): http://hdl.handle.net/10069/00041132
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp