一般注記application/pdf
Endothelial dysfunction is a key element in early atherogenesis. The purposes of this study were to evaluate the feasibility of magnetic resonance (MR) assessment of altered myocardial blood flow (MBF) in response to the cold pressor test (CPT), and to determine if coronary endothelial dysfunction in young smokers can be detected with this noninvasive approach. Fourteen healthy non-smokers (31 ± 6 years) and 12 smokers (34 ± 8 years) were studied. Breath-hold phase-contrast cine MR imaging (PC-MRI) of the coronary sinus (CS) were obtained at rest and during the CPT. MBF was measured as CS flow divided by LV mass and the rate pressure product. In non-smokers, MBF was 0.88 ± 0.19 ml/min/g at rest and significantly increased to 1.13 ± 0.26 ml/min/g during the CPT (P = 0.0001). In smokers, MBF was 0.94 ± 0.26 ml/min/g at rest and 0.96 ± 0.30 ml/min/g during the CPT (P = 0.73). MBF (MBF during the CPT − MBF at rest) was significantly reduced in smokers compared with non-smokers (0.02 ± 0.20 ml/min/g vs. 0.26 ± 0.18ml/min/g, P = 0.005). The intra-class correlation coefficient between measurements by two observers was 0.90 for MBF. A significant reduction in MBF response to CPT was demonstrated in young smokers with PC-MRI at 1.5 tesla. This noninvasive method has great potential for assessment of coronary endothelial function.
本文/Department of Radiology, Matsusaka Central Hospital, 102 Kobou, Kawai, Matsusaka, Mie 515-8566, Japan
31p
DOIinfo:doi/10.1007/s10554-014-0387-y
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2022-01-10T16:22:37+09:00
連携機関・データベース国立国会図書館 : 国立国会図書館デジタルコレクション