Altered coronary endothelial function in young smokers detected by magnetic resonance assessment of myocardial blood flow during the cold pressor test

• Material Type: 博士論文
• Title: Altered coronary endothelial function in young smokers detected by magnetic resonance assessment of myocardial blood flow during the cold pressor test
• Author/Editor: Ichikawa, Yasutaka
• Author Heading: Ichikawa, Yasutaka
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2014-03-25
• Publication Date (W3CDTF): 2014-03-25
• Degree Grantor: 三重大学
• Date Granted: 2014-03-25
• Date Granted (W3CDTF): 2014-03-25
• Dissertation Number: 乙医学第966号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第966号
• Text Language Code: eng
• Alias of Author: イチカワ, ヤスタカ; 市川, 泰崇
• Subject Heading: Coronary endothelial function; myocardial blood flow; cold pressor test; Magnetic resonance imaging; smoking
• Target Audience: 一般
• Note (General): application/pdf; Endothelial dysfunction is a key element in early atherogenesis. The purposes of this study were to evaluate the feasibility of magnetic resonance (MR) assessment of altered myocardial blood flow (MBF) in response to the cold pressor test (CPT), and to determine if coronary endothelial dysfunction in young smokers can be detected with this noninvasive approach. Fourteen healthy non-smokers (31 ± 6 years) and 12 smokers (34 ± 8 years) were studied. Breath-hold phase-contrast cine MR imaging (PC-MRI) of the coronary sinus (CS) were obtained at rest and during the CPT. MBF was measured as CS flow divided by LV mass and the rate pressure product. In non-smokers, MBF was 0.88 ± 0.19 ml/min/g at rest and significantly increased to 1.13 ± 0.26 ml/min/g during the CPT (P = 0.0001). In smokers, MBF was 0.94 ± 0.26 ml/min/g at rest and 0.96 ± 0.30 ml/min/g during the CPT (P = 0.73). MBF (MBF during the CPT − MBF at rest) was significantly reduced in smokers compared with non-smokers (0.02 ± 0.20 ml/min/g vs. 0.26 ± 0.18ml/min/g, P = 0.005). The intra-class correlation coefficient between measurements by two observers was 0.90 for MBF. A significant reduction in MBF response to CPT was demonstrated in young smokers with PC-MRI at 1.5 tesla. This noninvasive method has great potential for assessment of coronary endothelial function.; 本文/Department of Radiology, Matsusaka Central Hospital, 102 Kobou, Kawai, Matsusaka, Mie 515-8566, Japan; 31p
• DOI: info:doi/10.1007/s10554-014-0387-y; https://doi.org/info:doi/10.1007/s10554-014-0387-y
• Persistent ID (NDL): info:ndljp/pid/11977076; https://dl.ndl.go.jp/pid/11977076
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-01-10T16:22:37+09:00
• Date Created (W3CDTF): 2021-12-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00020041; https://mie-u.repo.nii.ac.jp/records/14423
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp