並列タイトル等ビタミンE添加状態のPorphyromonas gingivalisがヒト骨髄間葉系細胞の酸化ストレスに及ぼす影響
一般注記α-Tocopherol is the most physiologically active member of the vitamin E family, and its role as an antioxidant in various metabolic processes is widely recognized. However, vitamin E is often deficient in the human body, and only a few reports are available on the effects of periodontal disease on oxidative stress under vitamin E deficient conditions. We investigated the influence of the periodontal pathogen Porphyromonas gingivalis (P. gingivalis) on oxidative stress in human bone marrow mesenchymal cells (BMMCs) at low concentrations of α-tocopherol. We found an increase in H2O2 production at multiplicity of infection (MOI) of 100 and 1000 at earlier time points and with a concomitant decrease in SOD production. Catalase was produced regardless of P. gingivalis. These results suggest that P. gingivalis reduces the production of some antioxidant enzymes at low concentrations of α-tocopherol and affects the initial cell proliferation and H2O2 production.
2019年度
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2022-02-06T04:33:19+09:00
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