並列タイトル等抗菌剤を投与した2型糖尿病モデルラット口蓋粘膜の創傷治癒
一般注記We investigated the effect of antibiotic administration on spontaneous healing in Goto-Kakizaki (GK) rats with type 2 diabetes and an experimentally created defect in the palatal mucosa, comparing a control group of 18 male 8-week-old Wistar rats and a diabetes mellitus (DM) group of 18 male 8-week-old GK rats. In both groups, a cylindrical defect 1.5 mm in diameter was created in the maxillary right first molar region of the palatal mucosa using a biopsy punch to remove all the soft tissue, including the periosteum. Immediately after this surgery, an antibiotic was administered intraperitoneally. Three animals per group were sacrificed for histological testing at healing periods of 1, 3, 5, 7, 14 and 28 days after the surgery. It took longer for the wound to be covered with skin in the DM group than in the control group, and the appearance of granulation tissue and collagen fibers in the lamina propria was delayed. No sequestrum for-mation occurred in either group. The results of our comparative histological observations showed that spontaneous healing was delayed in GK rats compared with the controls. Our results suggest that if an antibiotic is administered, sequestrum formation may not occur.
2018年度
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2022-02-06T04:33:19+09:00
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