Palatal mucosal wound healing in type 2 diabetes model rats after administration of an antibacterial drug

Persistent ID (NDL): info:ndljp/pid/12071532

Material type: 博士論文

Author: 折原, 博一

Publisher: -

Publication date: 2019-03-27

Material Format: Digital

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Name of awarding university/degree: 大阪歯科大学,博士（歯学）

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Note (General)：: We investigated the effect of antibiotic administration on spontaneous healing in Goto-Kakizaki (GK) rats with type 2 diabetes and an experimentally c...

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Material Type: 博士論文
Title: Palatal mucosal wound healing in type 2 diabetes model rats after administration of an antibacterial drug
Author/Editor: 折原, 博一
Author Heading: 折原, 博一
Publication Date: 2019-03-27
Publication Date (W3CDTF): 2019-03-27
Alternative Title: 抗菌剤を投与した2型糖尿病モデルラット口蓋粘膜の創傷治癒
Degree grantor/type: 大阪歯科大学
Date Granted: 2019-03-27
Date Granted (W3CDTF): 2019-03-27
Dissertation Number: 乙第1618号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 乙第1618号
Text Language Code: eng
Subject Heading: Wound healing｜Diabetes mellitus｜Rats｜Wistar｜Antibacterial drug
Target Audience: 一般
Note (General): We investigated the effect of antibiotic administration on spontaneous healing in Goto-Kakizaki (GK) rats with type 2 diabetes and an experimentally created defect in the palatal mucosa, comparing a control group of 18 male 8-week-old Wistar rats and a diabetes mellitus (DM) group of 18 male 8-week-old GK rats. In both groups, a cylindrical defect 1.5 mm in diameter was created in the maxillary right first molar region of the palatal mucosa using a biopsy punch to remove all the soft tissue, including the periosteum. Immediately after this surgery, an antibiotic was administered intraperitoneally. Three animals per group were sacrificed for histological testing at healing periods of 1, 3, 5, 7, 14 and 28 days after the surgery. It took longer for the wound to be covered with skin in the DM group than in the control group, and the appearance of granulation tissue and collagen fibers in the lamina propria was delayed. No sequestrum for-mation occurred in either group. The results of our comparative histological observations showed that spontaneous healing was delayed in GK rats compared with the controls. Our results suggest that if an antibiotic is administered, sequestrum formation may not occur.
2018年度
Persistent ID (NDL): info:ndljp/pid/12071532
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Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
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Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-02-06T04:33:19+09:00
Date Created (W3CDTF): 2019-05-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1392/00000208/
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