並列タイトル等口腔扁平上皮癌におけるヒトパピローマウイルスの感染と癌化に関する研究
一般注記Human papillomavirus (HPV) is associated with the onset of oral dysplasia and oral squamous cell carcinoma (OSCC). In this study, we examined p53, p16INK4a, HPV 16/18 E6, and HPV L1 in oral papilloma (OP), oral dysplasia (OD), and OSCC to clarify the relationship between HPV infection and malignant transformation. We used 11 samples of OP, 14 of low grade oral dysplasia, 10 of high grade oral dysplasia, 21 of well to moderately differentiated squamous cell carcinomas (W-MSCC), and 8 of poorly differentiated squamous cell carcinomas in oral lesions obtained from Osaka Dental University Hospital. We performed immunohistochemical staining to study the expression of HPV 16/18 E6, HPV L1, p53, and p16INK4a in each lesion. Marked expression of p16INK4a was seen in HPV 16/18 E6 positive W-MSCC, and marked expression of p53 was seen in HPV L1 positive OD. These results suggest that HPV may play an important role in the transformation of p53 and p16INK4a, and that p16INK4a is a possible marker of HPV infection.
2016年度
機関リポジトリ記載の権利情報: CC BY-NC-ND
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