Study of infection and malignant transformation of human papillomavirus in oral squamous cell carcinoma
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- Material Type
- 博士論文
- Author/Editor
- 安田, 典泰
- Author Heading
- Publication Date
- 2017-03-10
- Publication Date (W3CDTF)
- 2017-03-10
- Alternative Title
- 口腔扁平上皮癌におけるヒトパピローマウイルスの感染と癌化に関する研究
- Degree Grantor
- 大阪歯科大学
- Date Granted
- 2017-03-10
- Date Granted (W3CDTF)
- 2017-03-10
- Dissertation Number
- 甲第810号
- Degree Type
- 博士（歯学）
- Conferring No. (Dissertation)
- 甲第810号
- Text Language Code
- eng
- Target Audience
- 一般
- Note (General)
- Human papillomavirus (HPV) is associated with the onset of oral dysplasia and oral squamous cell carcinoma (OSCC). In this study, we examined p53, p16INK4a, HPV 16/18 E6, and HPV L1 in oral papilloma (OP), oral dysplasia (OD), and OSCC to clarify the relationship between HPV infection and malignant transformation. We used 11 samples of OP, 14 of low grade oral dysplasia, 10 of high grade oral dysplasia, 21 of well to moderately differentiated squamous cell carcinomas (W-MSCC), and 8 of poorly differentiated squamous cell carcinomas in oral lesions obtained from Osaka Dental University Hospital. We performed immunohistochemical staining to study the expression of HPV 16/18 E6, HPV L1, p53, and p16INK4a in each lesion. Marked expression of p16INK4a was seen in HPV 16/18 E6 positive W-MSCC, and marked expression of p53 was seen in HPV L1 positive OD. These results suggest that HPV may play an important role in the transformation of p53 and p16INK4a, and that p16INK4a is a possible marker of HPV infection.2016年度機関リポジトリ記載の権利情報: CC BY-NC-ND
- Persistent ID (NDL)
- info:ndljp/pid/12071588
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- Acquisition Basis
- 博士論文（自動収集）
- Date Accepted (W3CDTF)
- 2022-02-06T04:33:19+09:00
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション