Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females

• 資料種別: 博士論文
• ISSN: 1349-6867
• タイトル: Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females
• 巻次・部編番号: 68 3-4
• 著者・編者: Beppu, Kana; Shono, Hitoshi; Kawakami, Ayuka; Takashi, Tomoe; Watanabe, Suzuno; Yoshida, Akari; Kuroda, Masashi; Fujimoto, Chisa; Kanamura, Ryo; Ohnishi, Hiroki; Kondo, Eiji; Azuma, Takahiro; Sato, Go; Kitamura, Yoshiaki; Tsutsumi, Rie; Sakaue, Hiroshi; Takeda, Noriaki
• 著者標目: Beppu, Kana; Shono, Hitoshi; Kawakami, Ayuka; Takashi, Tomoe; Watanabe, Suzuno; Yoshida, Akari; Kuroda, Masashi; Fujimoto, Chisa; Kanamura, Ryo; Ohnishi, Hiroki; Kondo, Eiji; Azuma, Takahiro; Sato, Go; Kitamura, Yoshiaki; Tsutsumi, Rie; Sakaue, Hiroshi; Takeda, Noriaki
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2021-08
• 出版年（W3CDTF）: 2021-08
• 並列タイトル等: グルタミン酸ナトリウムの食事への添加は健常女性のT1R3味覚受容体遺伝子発現の増加に伴いタンパク質、塩分、糖分摂取などのバランスの取れた食事をもたらす; monosodium glutamate increases T1R3 expression
• タイトル（掲載誌）: The Journal of Medical Investigation
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-16
• 授与年月日（W3CDTF）: 2022-03-16
• 報告番号: 甲第3589号
• 学位: 博士（医学）
• 博論授与番号: 甲第3589号
• 本文の言語コード: eng
• 件名標目: monosodium glutamate (MSG); T1R3 genes; dietary balance; taste 1 receptor 3 (T1R3); dysgeusia
• 対象利用者: 一般
• 一般注記: We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3 (T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed <10 g of MSG daily, whereas no alteration was observed in participants who consumed >10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance.
• DOI: info:doi/10.2152/jmi.68.315; https://doi.org/info:doi/10.2152/jmi.68.315
• 国立国会図書館永続的識別子: info:ndljp/pid/12263891; https://dl.ndl.go.jp/pid/12263891
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-05-09T11:57:37+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/116504
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp