Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females 3-4

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females
• Volume: 68 3-4
• Author/Editor: Beppu, Kana; Shono, Hitoshi; Kawakami, Ayuka; Takashi, Tomoe; Watanabe, Suzuno; Yoshida, Akari; Kuroda, Masashi; Fujimoto, Chisa; Kanamura, Ryo; Ohnishi, Hiroki; Kondo, Eiji; Azuma, Takahiro; Sato, Go; Kitamura, Yoshiaki; Tsutsumi, Rie; Sakaue, Hiroshi; Takeda, Noriaki
• Author Heading: Beppu, Kana; Shono, Hitoshi; Kawakami, Ayuka; Takashi, Tomoe; Watanabe, Suzuno; Yoshida, Akari; Kuroda, Masashi; Fujimoto, Chisa; Kanamura, Ryo; Ohnishi, Hiroki; Kondo, Eiji; Azuma, Takahiro; Sato, Go; Kitamura, Yoshiaki; Tsutsumi, Rie; Sakaue, Hiroshi; Takeda, Noriaki
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2021-08
• Publication Date (W3CDTF): 2021-08
• Alternative Title: グルタミン酸ナトリウムの食事への添加は健常女性のT1R3味覚受容体遺伝子発現の増加に伴いタンパク質、塩分、糖分摂取などのバランスの取れた食事をもたらす; monosodium glutamate increases T1R3 expression
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-16
• Date Granted (W3CDTF): 2022-03-16
• Dissertation Number: 甲第3589号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3589号
• Text Language Code: eng
• Subject Heading: monosodium glutamate (MSG); T1R3 genes; dietary balance; taste 1 receptor 3 (T1R3); dysgeusia
• Target Audience: 一般
• Note (General): We previously showed that chemotherapy-induced dysgeusia was associated with lingual taste receptor gene expression, and monosodium glutamate (MSG) improved dysgeusia by upregulating taste 1 receptor 3 (T1R3) gene expression. In recent years, decreased taste sensitivity has also been reported in some young people, and these are partly due to their disordered eating habits. From these background, we investigated the effects of MSG supplementation on taste receptor expression and dietary intake in healthy females. Fifteen young healthy volunteers were enrolled for the present crossover study and divided in two groups (dietary supplementation with MSG at 2.7 g / day or 0.27 g / day). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative PCR analysis. Food intake was assessed by food frequency questionnaire (FFQg), and body composition was measured using Omron HBF-701. T1R3 expression levels in the tongue and taste sensitivity increased significantly in participants who consumed <10 g of MSG daily, whereas no alteration was observed in participants who consumed >10 g of MSG daily. Furthermore, protein, fat, and carbohydrate (PFC) balance and salt and sugar intake improved by MSG supplementation. In conclusion, MSG supplementation increased T1R3 expression in the tongue and improved dietary balance.
• DOI: info:doi/10.2152/jmi.68.315; https://doi.org/info:doi/10.2152/jmi.68.315
• Persistent ID (NDL): info:ndljp/pid/12263891; https://dl.ndl.go.jp/pid/12263891
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-05-09T11:57:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116504
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp