並列タイトル等乳幼児の薬剤抵抗性てんかんに対する脳梁離断術後の発達予後
授与機関名Nagasaki University (長崎大学)
一般注記Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood.Methods: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients’ developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale.Results: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was −1.6 points (SD, 11.6). However, 42.5% of patients had a mean DQ increase of 6.5 points (SD, 6.4), one year after CC from that before surgery. Factors related to the improvement in postoperative DQ were ‘low preoperative DQ’, ‘developmental gain 1 month postoperatively’, and ‘postoperative seizure-free state’. Approximately 21.7% of patients were seizure-free 1 year after CC.Interpretation: Performing CC, in infancy and early childhood for patients with drug-resistant epilepsy and severe developmental impairment, was associated with improved development in 42.5% of patients. Remission of seizures, even if only for a short period, contributed to developmental improvement. From a developmental perspective, CC for drug-resistant epilepsy in early childhood is an effective treatment.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1444号 学位授与年月日:令和4年3月18日
Author: Ryoko Honda, Hiroshi Baba, Kohei Adachi, Rika Koshimoto, Tomonori Ono, Keisuke Toda, Shigeki Tanaka, Shiro Baba, Kazumi Yamasaki, Hiroshi Yatsuhashi
Citation: Epilepsy & Behavior, 117, art. no. 107799; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
http://hdl.handle.net/10069/00041447
DOIinfo:doi/10.1016/j.yebeh.2021.107799
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