Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy

• Material Type: 博士論文
• ISSN: 1525-5050
• Title: Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy
• Volume: 117
• Author/Editor: 本田, 涼子
• Author Heading: 本田, 涼子
• Publication, Distribution, etc.: Elsevier Inc.
• Publication Date: 2022-03-18
• Publication Date (W3CDTF): 2022-03-18
• Alternative Title: 乳幼児の薬剤抵抗性てんかんに対する脳梁離断術後の発達予後
• Periodical title: Epilepsy & Behavior
• Degree Grantor: Nagasaki University (長崎大学)
• Date Granted: 2022-03-18
• Date Granted (W3CDTF): 2022-03-18
• Dissertation Number: 甲医歯薬第1444号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1444号
• Text Language Code: eng
• Subject Heading: Corpus callosotomy; Developmental outcome; Seizure outcome; Infants and young children; Drug-resistant epilepsy
• Target Audience: 一般
• Note (General): Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood.Methods: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients’ developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale.Results: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was −1.6 points (SD, 11.6). However, 42.5% of patients had a mean DQ increase of 6.5 points (SD, 6.4), one year after CC from that before surgery. Factors related to the improvement in postoperative DQ were ‘low preoperative DQ’, ‘developmental gain 1 month postoperatively’, and ‘postoperative seizure-free state’. Approximately 21.7% of patients were seizure-free 1 year after CC.Interpretation: Performing CC, in infancy and early childhood for patients with drug-resistant epilepsy and severe developmental impairment, was associated with improved development in 42.5% of patients. Remission of seizures, even if only for a short period, contributed to developmental improvement. From a developmental perspective, CC for drug-resistant epilepsy in early childhood is an effective treatment.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1444号 学位授与年月日:令和4年3月18日; Author: Ryoko Honda, Hiroshi Baba, Kohei Adachi, Rika Koshimoto, Tomonori Ono, Keisuke Toda, Shigeki Tanaka, Shiro Baba, Kazumi Yamasaki, Hiroshi Yatsuhashi; Citation: Epilepsy & Behavior, 117, art. no. 107799; 2021; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18); http://hdl.handle.net/10069/00041447
• DOI: info:doi/10.1016/j.yebeh.2021.107799; https://doi.org/info:doi/10.1016/j.yebeh.2021.107799
• Persistent ID (NDL): info:ndljp/pid/12296391; https://dl.ndl.go.jp/pid/12296391
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Date Created (W3CDTF): 2022-05-27
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/00041447
• Periodical Title (URI): http://hdl.handle.net/10069/00041563
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp