CELL TYPE-SPECIFIC LOCALIZATION OF OPTINEURIN IN THE STRIATAL NEURONS OF MICE : IMPLICATIONS FOR NEURONAL VULNERABILITY IN HUNTINGTON'S DISEASE

• 資料種別: 博士論文
• ISSN: 0306-4522
• タイトル: CELL TYPE-SPECIFIC LOCALIZATION OF OPTINEURIN IN THE STRIATAL NEURONS OF MICE : IMPLICATIONS FOR NEURONAL VULNERABILITY IN HUNTINGTON'S DISEASE
• 巻次・部編番号: 202
• 著者・編者: Okita, Shinya; Morigaki, Ryoma; Koizumi, H.; Kaji, Ryuji; Nagahiro, Shinji; Goto, Satoshi
• 著者標目: Okita, Shinya; Morigaki, Ryoma; Koizumi, H.; Kaji, Ryuji; Nagahiro, Shinji; Goto, Satoshi
• 出版事項: Elsevier|International Brain Research Organization
• 出版年月日等: 2011-12-03
• 出版年（W3CDTF）: 2011-12-03
• 並列タイトル等: マウス線条体ニューロンにおけるオプチニューリンの細胞特異的局在 : ハンチントン病における神経脆弱性への影響
• タイトル（掲載誌）: Neuroscience
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-16
• 授与年月日（W3CDTF）: 2022-03-16
• 報告番号: 甲第3587号
• 学位: 博士（医学）
• 博論授与番号: 甲第3587号
• 本文の言語コード: eng
• 件名標目: Huntington's disease; optineurin; Huntingtin; medium spiny neuron; Tyramide Signal Amplification; striatum; interneurons; neurodegeneration
• 対象利用者: 一般
• 一般注記: Striatal neuropathology of Huntington's disease (HD) involves primary and progressive degeneration of the medium-sized projection neurons, with relative sparing of the local circuit interneurons. The mechanism for such a patterned cell loss in the HD striatum continues to remain unclear. Optineurin (OPTN) is one of the proteins interacting with huntingtin and plays a protective role in several neurodegenerative disorders. To determine the cellular localization pattern of OPTN in the mouse striatum, we employed a highly sensitive immunohistochemistry with the tyramide signal amplification system. In this study, we show that OPTN appeared as a cytoplasmic protein within the subsets of the striatal neurons. Of particular interest was that OPTN was abundantly expressed in the interneurons, whereas low levels of OPTN were observed in the medium projection neurons. This cell type-specific distribution of OPTN in the striatum is strikingly complementary to the pattern of neuronal loss typically observed in the striatum of patients with HD. We suggest that OPTN abundance is an important cellular factor in considering the cell type-specific vulnerability of striatal neurons in HD.
• DOI: info:doi/10.1016/j.neuroscience.2011.11.059; https://doi.org/info:doi/10.1016/j.neuroscience.2011.11.059
• 国立国会図書館永続的識別子: info:ndljp/pid/12296799; https://dl.ndl.go.jp/pid/12296799
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-06-05T18:01:14+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/116978
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp