CELL TYPE-SPECIFIC LOCALIZATION OF OPTINEURIN IN THE STRIATAL NEURONS OF MICE : IMPLICATIONS FOR NEURONAL VULNERABILITY IN HUNTINGTON'S DISEASE

• Material Type: 博士論文
• ISSN: 0306-4522
• Title: CELL TYPE-SPECIFIC LOCALIZATION OF OPTINEURIN IN THE STRIATAL NEURONS OF MICE : IMPLICATIONS FOR NEURONAL VULNERABILITY IN HUNTINGTON'S DISEASE
• Volume: 202
• Author/Editor: Okita, Shinya; Morigaki, Ryoma; Koizumi, H.; Kaji, Ryuji; Nagahiro, Shinji; Goto, Satoshi
• Author Heading: Okita, Shinya; Morigaki, Ryoma; Koizumi, H.; Kaji, Ryuji; Nagahiro, Shinji; Goto, Satoshi
• Publication, Distribution, etc.: Elsevier|International Brain Research Organization
• Publication Date: 2011-12-03
• Publication Date (W3CDTF): 2011-12-03
• Alternative Title: マウス線条体ニューロンにおけるオプチニューリンの細胞特異的局在 : ハンチントン病における神経脆弱性への影響
• Periodical title: Neuroscience
• Degree grantor/type: 徳島大学
• Date Granted: 2022-03-16
• Date Granted (W3CDTF): 2022-03-16
• Dissertation Number: 甲第3587号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3587号
• Text Language Code: eng
• Subject Heading: Huntington's disease; optineurin; Huntingtin; medium spiny neuron; Tyramide Signal Amplification; striatum; interneurons; neurodegeneration
• Target Audience: 一般
• Note (General): Striatal neuropathology of Huntington's disease (HD) involves primary and progressive degeneration of the medium-sized projection neurons, with relative sparing of the local circuit interneurons. The mechanism for such a patterned cell loss in the HD striatum continues to remain unclear. Optineurin (OPTN) is one of the proteins interacting with huntingtin and plays a protective role in several neurodegenerative disorders. To determine the cellular localization pattern of OPTN in the mouse striatum, we employed a highly sensitive immunohistochemistry with the tyramide signal amplification system. In this study, we show that OPTN appeared as a cytoplasmic protein within the subsets of the striatal neurons. Of particular interest was that OPTN was abundantly expressed in the interneurons, whereas low levels of OPTN were observed in the medium projection neurons. This cell type-specific distribution of OPTN in the striatum is strikingly complementary to the pattern of neuronal loss typically observed in the striatum of patients with HD. We suggest that OPTN abundance is an important cellular factor in considering the cell type-specific vulnerability of striatal neurons in HD.
• DOI: info:doi/10.1016/j.neuroscience.2011.11.059; https://doi.org/info:doi/10.1016/j.neuroscience.2011.11.059
• Persistent ID (NDL): info:ndljp/pid/12296799; https://dl.ndl.go.jp/pid/12296799
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-06-05T18:01:14+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116978
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp