授与機関名Nagasaki University (長崎大学)
一般注記Inverted internal limiting membrane (ILM) flap technique was developed to achieve macular hole (MH) closure in large MH and refractory cases. In this study, we evaluate the effect of the technique for small-medium size MH. We recruited patients who underwent vitrectomy for small-medium size (< 400 μm) MH with either inverted ILM flap technique (flap group) or with conventional ILM peeling (peeling group). Using propensity score, 21 eyes of 21 patients in the peeling group were matched against 21 eyes of 21 patients in the flap group. We compared MH closure rate, postoperative visual acuity, and recovery of the external limiting membrane (ELM) and ellipsoid zone (EZ). The MH closure rate was not different between the two groups (flap vs peeling: 90% vs 100%, P = 0.49). Whereas there was no significant difference in visual acuity improvement between the two groups, the flap group showed more disruption of the ELM 3 months after surgery and of the EZ at 3 and 6 months after surgery (P = 0.02, P = 0.03, and P = 0.04, respectively). The result suggested that inverted ILM flap technique does not have additional benefits for small-medium size MHs and may delay recovery of retinal integrity.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1403号 学位授与年月日:令和4年3月2日
Author: Kanako Yamada, Akio Oishi, Mao Kusano, Hirofumi Kinoshita, Eiko Tsuiki & Takashi Kitaoka
Citation: Scientific Reports, 12, art.no. 731; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-02)
http://hdl.handle.net/10069/00041406
DOIinfo:doi/10.1038/s41598-021-04739-x
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受理日（W3CDTF）2022-06-05T18:01:14+09:00
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