Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium

• 資料種別: 博士論文
• ISSN: 1600-0722
• タイトル: Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium
• 巻次・部編番号: 129 1
• 著者・編者: Rita, Rani Roy; Katsumitsu, Shimada; Satoshi, Murakami; Hiromasa, Hasegawa; Roy, Rita Rani; Shimada, Katsumi; Murakami, Satoshi; Hasegwa, Hiromasa
• 出版年月日等: 2021
• 出版年（W3CDTF）: 2021
• 並列タイトル等: 口腔粘膜上皮における角質化細胞エンベロープ形成へのトランスグルタミナーゼと基質たんぱく質の寄与
• タイトル（掲載誌）: European journal of oral sciences
• 授与機関名: 松本歯科大学
• 授与年月日: 2022-01-31
• 授与年月日（W3CDTF）: 2022-01-31
• 報告番号: 甲第246号
• 学位: 博士（歯学）
• 博論授与番号: 甲第246号
• 本文の言語コード: eng
• 件名標目: cornified envelope; keratinized oral epithelium; non-keratinized oral epithelium; substrates; transglutaminase
• 一般注記: Cornified envelope formation is crucial for the final differentiation of keratinized epithelium.However,the mechanisms of cornified envelope formation in the oral epithelium remain unclear.The aim of this study was to clarify the differences in the distribution and expression of cornified envelope related proteins and genes between keratinized and non-keratinized oral epithelia.We immunohistochemically investigated the distribution patterns of transglutaminase1(TG1),transglutaminase3(TG3),and their substrate proteins involucrin(IVL),loricrin(LOR),and small pro[1]line rich proteins(SPRs),in 19 keratinized and 14 non-keratinized oral epithelium samples.TG1 and TG3 mRNA levels were investigated in both types of epithelium by real time reverse transcription polymerase chain reaction(RT-PCR)using paraf[1]fin-embedded specimens.Data were analyzed to identify factors involved in cornified envelope formation.We demonstrate that 11 localization patterns show statistically significant differences between keratinized and non-keratinized oral epithelia.These factors clearly drove the separation of the two groups during cluster analysis.TG1 mRNA levels in keratinized oral epithelium were significantly higher than those in non-keratinized oral epithelium.In conclusion,the characteristic distribution of trans[1]glutaminases and their substrates and the mRNA levels of TG1 can regulate cornified envelope formation in keratinized oral epithelium, together with the contribution of TG3 first reported in this paper; 2021; identifier:甲第246号; PubMed番号 : 33501693; 元資料の権利情報 : © 2021 European Journal of Oral Sciences; 元資料の権利情報 : CC BY; 開始ページ : e12760
• 国立国会図書館永続的識別子: info:ndljp/pid/12303088; https://dl.ndl.go.jp/pid/12303088
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-07-05T02:30:21+09:00
• 作成日（W3CDTF）: 2022-06-20
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 原資料（URI）: 雑誌掲載論文（電子版）; https://onlinelibrary.wiley.com/doi/full/10.1111/eos.12760
• 掲載誌（URI）: http://id.nii.ac.jp/1070/00002988/
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp