Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium

• Material Type: 博士論文
• ISSN: 1600-0722
• Title: Contribution of transglutaminases and their substrate proteins to the formation of cornified cell envelope in oral mucosal epithelium
• Volume: 129 1
• Author/Editor: Rita, Rani Roy; Katsumitsu, Shimada; Satoshi, Murakami; Hiromasa, Hasegawa; Roy, Rita Rani; Shimada, Katsumi; Murakami, Satoshi; Hasegwa, Hiromasa
• Publication Date: 2021
• Publication Date (W3CDTF): 2021
• Alternative Title: 口腔粘膜上皮における角質化細胞エンベロープ形成へのトランスグルタミナーゼと基質たんぱく質の寄与
• Periodical title: European journal of oral sciences
• Degree grantor/type: 松本歯科大学
• Date Granted: 2022-01-31
• Date Granted (W3CDTF): 2022-01-31
• Dissertation Number: 甲第246号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第246号
• Text Language Code: eng
• Subject Heading: cornified envelope; keratinized oral epithelium; non-keratinized oral epithelium; substrates; transglutaminase
• Note (General): Cornified envelope formation is crucial for the final differentiation of keratinized epithelium.However,the mechanisms of cornified envelope formation in the oral epithelium remain unclear.The aim of this study was to clarify the differences in the distribution and expression of cornified envelope related proteins and genes between keratinized and non-keratinized oral epithelia.We immunohistochemically investigated the distribution patterns of transglutaminase1(TG1),transglutaminase3(TG3),and their substrate proteins involucrin(IVL),loricrin(LOR),and small pro[1]line rich proteins(SPRs),in 19 keratinized and 14 non-keratinized oral epithelium samples.TG1 and TG3 mRNA levels were investigated in both types of epithelium by real time reverse transcription polymerase chain reaction(RT-PCR)using paraf[1]fin-embedded specimens.Data were analyzed to identify factors involved in cornified envelope formation.We demonstrate that 11 localization patterns show statistically significant differences between keratinized and non-keratinized oral epithelia.These factors clearly drove the separation of the two groups during cluster analysis.TG1 mRNA levels in keratinized oral epithelium were significantly higher than those in non-keratinized oral epithelium.In conclusion,the characteristic distribution of trans[1]glutaminases and their substrates and the mRNA levels of TG1 can regulate cornified envelope formation in keratinized oral epithelium, together with the contribution of TG3 first reported in this paper; 2021; identifier:甲第246号; PubMed番号 : 33501693; 元資料の権利情報 : © 2021 European Journal of Oral Sciences; 元資料の権利情報 : CC BY; 開始ページ : e12760
• Persistent ID (NDL): info:ndljp/pid/12303088; https://dl.ndl.go.jp/pid/12303088
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-07-05T02:30:21+09:00
• Date Created (W3CDTF): 2022-06-20
• Format (IMT): PDF
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• Original Material (URI): 雑誌掲載論文（電子版）; https://onlinelibrary.wiley.com/doi/full/10.1111/eos.12760
• Periodical Title (URI): http://id.nii.ac.jp/1070/00002988/
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp