粉末経鼻投与システムを用いたカニクイザルにおけるOVA経鼻投与後の全身及び粘膜免疫の誘導評価

• 資料種別: 博士論文
• タイトル: 粉末経鼻投与システムを用いたカニクイザルにおけるOVA経鼻投与後の全身及び粘膜免疫の誘導評価
• 著者・編者: 鳥飼, 祐介
• 著者標目: 鳥飼, 祐介
• 出版事項: Elsevier
• 出版年月日等: 2021-07-15
• 出版年（W3CDTF）: 2021-07-15
• 並列タイトル等: Evaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus Monkeys
• 授与機関名: 鹿児島大学
• 授与年月日: 2021-07-15
• 授与年月日（W3CDTF）: 2021-07-15
• 報告番号: 甲総研第613号
• 学位: 博士(医学); Doctor of Philosophy in Medical Science
• 博論授与番号: 甲総研第613号
• 本文の言語コード: eng
• 件名標目: Controlled delivery; Controlled release; Drug delivery system; Formulation; Immunogenicity; Mucoadhesive; Mucosal vaccination; Powder technology; Nasal drug delivery; Vaccine
• NDC: 490
• 対象利用者: 一般
• 一般注記: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; An immune response for a nasal ovalbumin (OVA) powder formulation with an applied nasal delivery platform technology, consisting of a powdery nasal carrier and a device, was evaluated in monkeys with similar upper respiratory tracts and immune systems to those of humans, in order to assess the applicability to a vaccine antigen. Nasal distribution and retention studies using a 3D nasal cavity model and manganese-enhanced MRI were conducted by administering nasal dye and manganese powder formulations with the applied technology. Systemic and mucosal immune responses for the nasal OVA powder formulation were evaluated by determining serum IgG and nasal wash IgA antibody titers. The nasal dye and manganese powder formulations showed wider distribution and longer retention time than did a nasal liquid formulation. The nasal OVA powder formulation also showed comparable and higher antigen-specific IgG antibody titer to an injection and nasal liquid formulation, respectively. Furthermore, antigen-specific IgA antibody response was detected only for the nasal OVA powder formulation. The present study suggests that the technology, originally designed for drug absorption, is promising for nasal vaccines, enabling both a mucosal immunity response as the first line of defense and systemic immunity response as a second line of defense against infection.Yusuke Torikai, Yuji Sasaki, Keita Sasaki, Akifumi Kyunob, Shunji Haruta, Akihide TanimotoEvaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus MonkeysJournal of Pharmaceutical Sciences 110(5), 2021, P.2038-2046https://doi.org/10.1016/j.xphs.2020.11.023
• 国立国会図書館永続的識別子: info:ndljp/pid/12304666; https://dl.ndl.go.jp/pid/12304666
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-07-05T02:30:21+09:00
• 作成日（W3CDTF）: 2021-08-19
• 記録形式（IMT）: PDF; application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10232/00031778
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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