粉末経鼻投与システムを用いたカニクイザルにおけるOVA経鼻投与後の全身及び粘膜免疫の誘導評価

• Material Type: 博士論文
• Title: 粉末経鼻投与システムを用いたカニクイザルにおけるOVA経鼻投与後の全身及び粘膜免疫の誘導評価
• Author/Editor: 鳥飼, 祐介
• Author Heading: 鳥飼, 祐介
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2021-07-15
• Publication Date (W3CDTF): 2021-07-15
• Alternative Title: Evaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus Monkeys
• Degree grantor/type: 鹿児島大学
• Date Granted: 2021-07-15
• Date Granted (W3CDTF): 2021-07-15
• Dissertation Number: 甲総研第613号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第613号
• Text Language Code: eng
• Subject Heading: Controlled delivery; Controlled release; Drug delivery system; Formulation; Immunogenicity; Mucoadhesive; Mucosal vaccination; Powder technology; Nasal drug delivery; Vaccine
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; An immune response for a nasal ovalbumin (OVA) powder formulation with an applied nasal delivery platform technology, consisting of a powdery nasal carrier and a device, was evaluated in monkeys with similar upper respiratory tracts and immune systems to those of humans, in order to assess the applicability to a vaccine antigen. Nasal distribution and retention studies using a 3D nasal cavity model and manganese-enhanced MRI were conducted by administering nasal dye and manganese powder formulations with the applied technology. Systemic and mucosal immune responses for the nasal OVA powder formulation were evaluated by determining serum IgG and nasal wash IgA antibody titers. The nasal dye and manganese powder formulations showed wider distribution and longer retention time than did a nasal liquid formulation. The nasal OVA powder formulation also showed comparable and higher antigen-specific IgG antibody titer to an injection and nasal liquid formulation, respectively. Furthermore, antigen-specific IgA antibody response was detected only for the nasal OVA powder formulation. The present study suggests that the technology, originally designed for drug absorption, is promising for nasal vaccines, enabling both a mucosal immunity response as the first line of defense and systemic immunity response as a second line of defense against infection.Yusuke Torikai, Yuji Sasaki, Keita Sasaki, Akifumi Kyunob, Shunji Haruta, Akihide TanimotoEvaluation of Systemic and Mucosal Immune Responses Induced by a Nasal Powder Delivery System in Conjunction with an OVA Antigen in Cynomolgus MonkeysJournal of Pharmaceutical Sciences 110(5), 2021, P.2038-2046https://doi.org/10.1016/j.xphs.2020.11.023
• Persistent ID (NDL): info:ndljp/pid/12304666; https://dl.ndl.go.jp/pid/12304666
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2022-07-05T02:30:21+09:00
• Date Created (W3CDTF): 2021-08-19
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00031778
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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