Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells

• 資料種別: 博士論文
• ISSN: 0250-7005
• タイトル: Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells
• 巻次・部編番号: 42 4
• 著者・編者: 大橋, 和明
• 著者標目: 大橋, 和明
• 出版事項: International Institute of Anticancer Research
• 出版年月日等: 2022-06-01
• 出版年（W3CDTF）: 2022-06-01
• 並列タイトル等: 卵巣癌関連線維芽細胞と対側の正常卵巣由来間葉系幹細胞における生物学的特性の相違に関する検討
• タイトル（掲載誌）: ANTICANCER RESEARCH
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-06-01
• 授与年月日（W3CDTF）: 2022-06-01
• 報告番号: 甲医歯薬第1454号
• 学位: 博士(医学)
• 博論授与番号: 甲医歯薬第1454号
• 本文の言語コード: eng
• 件名標目: Cancer-associated fibroblasts; ovarian cancer; stromal cells; mesenchymal stem cells; normal ovary
• 対象利用者: 一般
• 一般注記: Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ovary-derived mesenchymal stem cells (NO-MSCs). Materials and Methods: Surgically resected ovarian cancer and contralateral normal ovarian tissue samples were cut into small pieces for culture as “explants”. The number of outgrown cells, their proliferative kinetics, and expression levels of cell surface markers of CAFs, as well as three miRNAs in OCa-CAFs and NO-MSCs were compared directly. Differentially expressed genes between both groups were also investigated. Results: Comparable numbers of outgrown cells were harvested from both groups. Significantly higher expression of α-smooth muscle actin and miR-142 was found in OCa-CAFs, which decreased significantly during ex vivo cell expansion. A total of 21 differentially expressed genes were identified between both groups. Conclusion: OCa-CAFs showed different biological properties in direct comparison with NO-MSCs, which might play major roles in the pathogenesis of ovarian cancer.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1454号 学位授与年月日:令和4年6月1日; Author: Kazuaki Ohashi, Tao-Sheng Li, Shoko Miura, Yuri Hasegawa and Kiyonori Miura; Citation: ANTICANCER RESEARCH, 42(4), pp.1729-1737; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01); http://hdl.handle.net/10069/00041584
• DOI: info:doi/10.21873/anticanres.15649; https://doi.org/info:doi/10.21873/anticanres.15649
• 国立国会図書館永続的識別子: info:ndljp/pid/12313717; https://dl.ndl.go.jp/pid/12313717
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2022-08-08T06:02:54+09:00
• 作成日（W3CDTF）: 2022-07-15
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 関連情報（URI）: http://hdl.handle.net/10069/00041584
• 掲載誌（URI）: http://hdl.handle.net/10069/00041618
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp