Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells

Persistent ID (NDL): info:ndljp/pid/12313717

Material type: 博士論文

Author: 大橋, 和明

Publisher: International Institute of Anticancer Research

Publication date: 2022-06-01

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ova...

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Material Type: 博士論文
ISSN: 0250-7005
Title: Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells
Volume: 42 4
Author/Editor: 大橋, 和明
Author Heading: 大橋, 和明
Publication, Distribution, etc.: International Institute of Anticancer Research
Publication Date: 2022-06-01
Publication Date (W3CDTF): 2022-06-01
Alternative Title: 卵巣癌関連線維芽細胞と対側の正常卵巣由来間葉系幹細胞における生物学的特性の相違に関する検討
Periodical title: ANTICANCER RESEARCH
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2022-06-01
Date Granted (W3CDTF): 2022-06-01
Dissertation Number: 甲医歯薬第1454号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲医歯薬第1454号
Text Language Code: eng
Subject Heading: Cancer-associated fibroblasts
ovarian cancer
stromal cells
mesenchymal stem cells
normal ovary
Target Audience: 一般
Note (General): Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ovary-derived mesenchymal stem cells (NO-MSCs). Materials and Methods: Surgically resected ovarian cancer and contralateral normal ovarian tissue samples were cut into small pieces for culture as “explants”. The number of outgrown cells, their proliferative kinetics, and expression levels of cell surface markers of CAFs, as well as three miRNAs in OCa-CAFs and NO-MSCs were compared directly. Differentially expressed genes between both groups were also investigated. Results: Comparable numbers of outgrown cells were harvested from both groups. Significantly higher expression of α-smooth muscle actin and miR-142 was found in OCa-CAFs, which decreased significantly during ex vivo cell expansion. A total of 21 differentially expressed genes were identified between both groups. Conclusion: OCa-CAFs showed different biological properties in direct comparison with NO-MSCs, which might play major roles in the pathogenesis of ovarian cancer.
長崎大学学位論文学位記番号:博(医歯薬)甲第1454号学位授与年月日:令和4年6月1日
Author: Kazuaki Ohashi, Tao-Sheng Li, Shoko Miura, Yuri Hasegawa and Kiyonori Miura
Citation: ANTICANCER RESEARCH, 42(4), pp.1729-1737; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01)
http://hdl.handle.net/10069/00041584
DOI: info:doi/10.21873/anticanres.15649
https://doi.org/info:doi/10.21873/anticanres.15649
Persistent ID (NDL): info:ndljp/pid/12313717
https://dl.ndl.go.jp/pid/12313717
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2022-08-08T06:02:54+09:00
Date Created (W3CDTF): 2022-07-15
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Related Material (URI): http://hdl.handle.net/10069/00041584
Periodical Title (URI): http://hdl.handle.net/10069/00041618
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp