日本人の健診データを用いた高血圧発症リスク予測スコアの開発

• 資料種別: 博士論文
• タイトル: 日本人の健診データを用いた高血圧発症リスク予測スコアの開発
• 著者・編者: 川添, 真理子
• 著者標目: 川添, 真理子
• 出版事項: Springer Nature
• 出版年月日等: 2022-05-30
• 出版年（W3CDTF）: 2022-05-30
• 並列タイトル等: Development of a risk prediction score for hypertension incidence using Japanese health checkup data
• 授与機関名: 鹿児島大学
• 授与年月日: 2022-05-30
• 授与年月日（W3CDTF）: 2022-05-30
• 報告番号: 甲総研第662号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: Diabetes; Hypertension; Obesity; Prediction score; Smoking
• 対象利用者: 一般
• 一般注記: 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Hypertension is a risk factor for cardiovascular disease. We developed a simple scoring method for predicting future hypertension using health checkup data. A total of 41,902 participants aged 30–69 years without baseline hypertension who underwent annual health checkups (mean age, 52.3 ± 10.2 years; male, 47.7%) were included. They were randomly assigned to derivation (n = 27,935) and validation cohorts (n = 13,967) at a ratio of 2:1. In the derivation cohort, we performed multivariable logistic regression analysis and assigned scores to each factor significantly associated with 5-year hypertension. We evaluated the predictive ability of the scores using area under the curve (AUC) analysis and then applied them to the validation cohort to assess their validity. The score including items requiring blood sampling ranged from 0 to 14 and included seven indicators (age, body mass index, blood pressure, current smoking, family history of hypertension, diabetes, and hyperuricemia). The score not including items requiring blood sampling ranged from 0 to 12 and included five indicators (the above indicators, except diabetes and hyperuricemia). The score not including items requiring blood sampling was better; blood sampling did not improve diagnostic ability. The AUC of the score not including items requiring blood sampling was 0.76, with a sensitivity and specificity of 0.82 and 0.60, respectively, for scores ≥6 points. The incidence of hypertension gradually and constantly increased (from 0.9 to 49.6%) as the score increased from 0 to ≥10. Analysis in the validation cohort yielded similar results. We developed a simple and useful clinical prediction model to predict the 5-year incidence of hypertension among a general Japanese population. The model had reasonably high predictive ability and reproducibility.Mariko Kawasoe, Shin Kawasoe, Takuro Kubozono, Satoko Ojima, Takeko Kawabata, Yoshiyuki Ikeda, Naoya Oketani, Hironori Miyahara, Koichi Tokushige, Masaaki Miyata & Mitsuru OhishiDevelopment of a risk prediction score for hypertension incidence using Japanese health checkup dataHypertension Research (2022) 45:730–740This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:https://doi.org/10.1038/s41440-021-00831-x
• 国立国会図書館永続的識別子: info:ndljp/pid/12314353; https://dl.ndl.go.jp/pid/12314353
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 記録形式（IMT）: PDF; application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10232/00032020
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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