日本人の健診データを用いた高血圧発症リスク予測スコアの開発

• Material Type: 博士論文
• Title: 日本人の健診データを用いた高血圧発症リスク予測スコアの開発
• Author/Editor: 川添, 真理子
• Author Heading: 川添, 真理子
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-05-30
• Publication Date (W3CDTF): 2022-05-30
• Alternative Title: Development of a risk prediction score for hypertension incidence using Japanese health checkup data
• Degree Grantor: 鹿児島大学
• Date Granted: 2022-05-30
• Date Granted (W3CDTF): 2022-05-30
• Dissertation Number: 甲総研第662号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Diabetes; Hypertension; Obesity; Prediction score; Smoking
• Target Audience: 一般
• Note (General): 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Hypertension is a risk factor for cardiovascular disease. We developed a simple scoring method for predicting future hypertension using health checkup data. A total of 41,902 participants aged 30–69 years without baseline hypertension who underwent annual health checkups (mean age, 52.3 ± 10.2 years; male, 47.7%) were included. They were randomly assigned to derivation (n = 27,935) and validation cohorts (n = 13,967) at a ratio of 2:1. In the derivation cohort, we performed multivariable logistic regression analysis and assigned scores to each factor significantly associated with 5-year hypertension. We evaluated the predictive ability of the scores using area under the curve (AUC) analysis and then applied them to the validation cohort to assess their validity. The score including items requiring blood sampling ranged from 0 to 14 and included seven indicators (age, body mass index, blood pressure, current smoking, family history of hypertension, diabetes, and hyperuricemia). The score not including items requiring blood sampling ranged from 0 to 12 and included five indicators (the above indicators, except diabetes and hyperuricemia). The score not including items requiring blood sampling was better; blood sampling did not improve diagnostic ability. The AUC of the score not including items requiring blood sampling was 0.76, with a sensitivity and specificity of 0.82 and 0.60, respectively, for scores ≥6 points. The incidence of hypertension gradually and constantly increased (from 0.9 to 49.6%) as the score increased from 0 to ≥10. Analysis in the validation cohort yielded similar results. We developed a simple and useful clinical prediction model to predict the 5-year incidence of hypertension among a general Japanese population. The model had reasonably high predictive ability and reproducibility.Mariko Kawasoe, Shin Kawasoe, Takuro Kubozono, Satoko Ojima, Takeko Kawabata, Yoshiyuki Ikeda, Naoya Oketani, Hironori Miyahara, Koichi Tokushige, Masaaki Miyata & Mitsuru OhishiDevelopment of a risk prediction score for hypertension incidence using Japanese health checkup dataHypertension Research (2022) 45:730–740This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:https://doi.org/10.1038/s41440-021-00831-x
• Persistent ID (NDL): info:ndljp/pid/12314353; https://dl.ndl.go.jp/pid/12314353
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• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Periodical Title (URI): http://hdl.handle.net/10232/00032020
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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