並列タイトル等Physiological functions and diseases of glycans
一般注記In this study, the physiological functions of glycans in five research items across species were investigated, and then their associations with muscular dystrophy, colorectal carcinoma and viral infection were examined. The following results were shown for each research item. (1)The deficiency of O-mannosyl glycan synthesis in Drosophila showed a “twisted abdomen” phenotype, which was shown to be a model for muscular dystrophy. (2) Novel β1,3-GalT, which synthesizes insect-specific N-type glycans containing T antigen in the brain of honeybees, was identified and a consensus sequence of active motifs was proposed. (3) PAPST-mediated sulfation is involved in the proliferation of colorectal cancer cells. (4) The sulfated glycan structure extracted by data mining enhances influenza virus infection. (5) Furthermore, this glycan structure is involved in the efficient propagation of human influenza virus to chicken egg.
コレクション（個別）国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
受理日（W3CDTF）2023-10-11T15:41:03+09:00
連携機関・データベース国立国会図書館 : 国立国会図書館デジタルコレクション