糖鎖の生理機能と疾患

Persistent ID (NDL): info:ndljp/pid/13023750

Material type: 博士論文

Author: 堀, 智美ほか

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Publication date: 2022-09-10

Material Format: Digital

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Name of awarding university/degree: 創価大学,博士（工学）

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Note (General)：: In this study, the physiological functions of glycans in five research items across species were investigated, and then their associations with muscul...

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Material Type: 博士論文
Title: 糖鎖の生理機能と疾患
Author/Editor: 堀, 智美
Tomomi, HORI
Author Heading: 堀, 智美
Tomomi, HORI
Publication Date: 2022-09-10
Publication Date (W3CDTF): 2022-09-10
Alternative Title: Physiological functions and diseases of glycans
Degree grantor/type: 創価大学
Date Granted: 2022-09-10
Date Granted (W3CDTF): 2022-09-10
Dissertation Number: 乙第26号
Degree Type: 博士（工学）
Text Language Code: jpn
Subject Heading: 糖鎖,糖転移酵素
筋ジストロフィー
昆虫
硫酸化
輸送体
大腸癌
データマイニング
インフルエンザウイルス
感染
発育鶏卵馴化
Target Audience: 一般
Note (General): In this study, the physiological functions of glycans in five research items across species were investigated, and then their associations with muscular dystrophy, colorectal carcinoma and viral infection were examined. The following results were shown for each research item. (1)The deficiency of O-mannosyl glycan synthesis in Drosophila showed a “twisted abdomen” phenotype, which was shown to be a model for muscular dystrophy. (2) Novel β1,3-GalT, which synthesizes insect-specific N-type glycans containing T antigen in the brain of honeybees, was identified and a consensus sequence of active motifs was proposed. (3) PAPST-mediated sulfation is involved in the proliferation of colorectal cancer cells. (4) The sulfated glycan structure extracted by data mining enhances influenza virus infection. (5) Furthermore, this glycan structure is involved in the efficient propagation of human influenza virus to chicken egg.
Persistent ID (NDL): info:ndljp/pid/13023750
https://dl.ndl.go.jp/pid/13023750
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-10-11T15:41:03+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10911/00040920
https://soka.repo.nii.ac.jp/records/40927
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