Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction

• 資料種別: 博士論文
• タイトル: Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction
• 著者・編者: Hashimoto, Yukihiro; Soeda, Tsunenari; Seno, Ayako; Okayama, Satoshi; Fukuda, Nozomi; Yano, Hiroki; Iwai, Atsushi; Nogi, Kazutaka; Hirai, Kaeko; Fujimoto, Hajime; Suzuki, Megumi; Iwama, Hajime; Nakai, Takehito; Doi, Naofumi; Saito, Yoshihiko
• 著者標目: Hashimoto, Yukihiro; Soeda, Tsunenari; Seno, Ayako; Okayama, Satoshi; Fukuda, Nozomi; Yano, Hiroki; Iwai, Atsushi; Nogi, Kazutaka; Hirai, Kaeko; Fujimoto, Hajime; Suzuki, Megumi; Iwama, Hajime; Nakai, Takehito; Doi, Naofumi; Saito, Yoshihiko
• 出版事項: Japanese Circulation Society
• 出版年月日等: 2022-11-25
• 出版年（W3CDTF）: 2022-11-25
• 並列タイトル等: 再灌流後急性心筋梗塞患者におけるリバースリモデリングと非造影T1低信号梗塞コア
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2023-03-15
• 授与年月日（W3CDTF）: 2023-03-15
• 報告番号: 乙第1529号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Acute myocardial infarction; Cardiac magnetic resonance imaging; Native T1 mapping; Reverse remodeling; T1 hypointense infarct core
• 対象利用者: 一般
• 一般注記: type:Thesis; Background: Non-contrast T1 hypointense infarct cores (ICs) within infarcted myocardium detected using cardiac magnetic resonanceimaging (CMR) T1 mapping may help assess the severity of left ventricular (LV) injury. However, because the relationship ofICs with chronic LV reverse remodeling (LVRR) is unknown, this study aimed to clarify it.Methods and Results: We enrolled patients with reperfused AMI who underwent baseline CMR on day-7 post-primary percutaneouscoronary intervention (n=109) and 12-month follow-up CMR (n=94). Correlations between ICs and chronic LVRR (end-systolicvolume decrease ≥15% at 12-month follow-up from baseline CMR) were investigated. We detected 52 (47.7%) ICs on baseline CMRby non-contrast-T1 mapping. LVRR was found in 52.1% of patients with reperfused AMI at 12-month follow-up. Patients with ICsdemonstrated higher peak creatine kinase levels, higher B-type natriuretic peptide levels at discharge, lower LV ejection fraction atdischarge, and lower incidence of LVRR than those without ICs (26.5% vs. 73.3%, P<0.001) at follow-up. Multivariate logistic regressionanalysis showed that the presence of ICs was an independent and the strongest negative predictor for LVRR at 12-month followup(hazard ratio: 0.087, 95% confidence interval: 0.017–0.459, P=0.004). Peak creatine kinase levels, native T1 values at myocardialedema, and myocardial salvaged indices also correlated with ICs.Conclusions: ICs detected by non-contrast-T1 mapping with 3.0-T CMR were an independent negative predictor of LVRR in patientswith reperfused AMI.; 博士（医学）・乙第1529号・令和5年3月15日; © 2022, THE JAPANESE CIRCULATION SOCIETYThis article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.; identifier:Circulation journal Vol.86 No.12 p.1968-1979 (2022 Nov); identifier:13469843; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4114; identifier:Circulation journal, 86(12): 1968-1979
• 国立国会図書館永続的識別子: info:ndljp/pid/13120204; https://dl.ndl.go.jp/pid/13120204
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2023-12-05T21:41:07+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/4114
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp