Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction

• Material Type: 博士論文
• Title: Reverse Remodeling and Non-Contrast T1 Hypointense Infarct Core in Patients With Reperfused Acute Myocardial Infarction
• Author/Editor: Hashimoto, Yukihiro; Soeda, Tsunenari; Seno, Ayako; Okayama, Satoshi; Fukuda, Nozomi; Yano, Hiroki; Iwai, Atsushi; Nogi, Kazutaka; Hirai, Kaeko; Fujimoto, Hajime; Suzuki, Megumi; Iwama, Hajime; Nakai, Takehito; Doi, Naofumi; Saito, Yoshihiko
• Author Heading: Hashimoto, Yukihiro; Soeda, Tsunenari; Seno, Ayako; Okayama, Satoshi; Fukuda, Nozomi; Yano, Hiroki; Iwai, Atsushi; Nogi, Kazutaka; Hirai, Kaeko; Fujimoto, Hajime; Suzuki, Megumi; Iwama, Hajime; Nakai, Takehito; Doi, Naofumi; Saito, Yoshihiko
• Publication, Distribution, etc.: Japanese Circulation Society
• Publication Date: 2022-11-25
• Publication Date (W3CDTF): 2022-11-25
• Alternative Title: 再灌流後急性心筋梗塞患者におけるリバースリモデリングと非造影T1低信号梗塞コア
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2023-03-15
• Date Granted (W3CDTF): 2023-03-15
• Dissertation Number: 乙第1529号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Acute myocardial infarction; Cardiac magnetic resonance imaging; Native T1 mapping; Reverse remodeling; T1 hypointense infarct core
• Target Audience: 一般
• Note (General): type:Thesis; Background: Non-contrast T1 hypointense infarct cores (ICs) within infarcted myocardium detected using cardiac magnetic resonanceimaging (CMR) T1 mapping may help assess the severity of left ventricular (LV) injury. However, because the relationship ofICs with chronic LV reverse remodeling (LVRR) is unknown, this study aimed to clarify it.Methods and Results: We enrolled patients with reperfused AMI who underwent baseline CMR on day-7 post-primary percutaneouscoronary intervention (n=109) and 12-month follow-up CMR (n=94). Correlations between ICs and chronic LVRR (end-systolicvolume decrease ≥15% at 12-month follow-up from baseline CMR) were investigated. We detected 52 (47.7%) ICs on baseline CMRby non-contrast-T1 mapping. LVRR was found in 52.1% of patients with reperfused AMI at 12-month follow-up. Patients with ICsdemonstrated higher peak creatine kinase levels, higher B-type natriuretic peptide levels at discharge, lower LV ejection fraction atdischarge, and lower incidence of LVRR than those without ICs (26.5% vs. 73.3%, P<0.001) at follow-up. Multivariate logistic regressionanalysis showed that the presence of ICs was an independent and the strongest negative predictor for LVRR at 12-month followup(hazard ratio: 0.087, 95% confidence interval: 0.017–0.459, P=0.004). Peak creatine kinase levels, native T1 values at myocardialedema, and myocardial salvaged indices also correlated with ICs.Conclusions: ICs detected by non-contrast-T1 mapping with 3.0-T CMR were an independent negative predictor of LVRR in patientswith reperfused AMI.; 博士（医学）・乙第1529号・令和5年3月15日; © 2022, THE JAPANESE CIRCULATION SOCIETYThis article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.; identifier:Circulation journal Vol.86 No.12 p.1968-1979 (2022 Nov); identifier:13469843; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4114; identifier:Circulation journal, 86(12): 1968-1979
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• Date Accepted (W3CDTF): 2023-12-05T21:41:07+09:00
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• Periodical Title (URI): http://hdl.handle.net/10564/4114
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