Antiglycative effect and Antiviral effect of Kuromoji (Lindera umbellata Thunb) extract

• 資料種別: 記事
• タイトル: Antiglycative effect and Antiviral effect of Kuromoji (Lindera umbellata Thunb) extract
• 著者・編者: Akihiko Shimobe; Bunichiro Ashibe; Shigeru Matsumi
• 出版事項: 日本 : 糖化ストレス研究会
• 出版年月日等: 2022-12-31
• 出版年（W3CDTF）: 2022-12-31
• 並列タイトル等: クロモジエキスの抗糖化作用、抗ウイルス作用
• タイトル（掲載誌）: Glycative stress research
• 巻号年月日等（掲載誌）: 9(4)
• 掲載巻: 9(4)
• ISSN（掲載誌）: 2188-3610
• ISSN-L（掲載誌）: 2188-3610
• 本文の言語コード: eng; jpn
• DOI: 10.24659/gsr.9.4_221; https://doi.org/10.24659/gsr.9.4_221
• 国立国会図書館永続的識別子: info:ndljp/pid/13120791; https://dl.ndl.go.jp/pid/13120791
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: オンライン資料収集制度
• 受理日（W3CDTF）: 2023-12-08T11:19:22+09:00
• 保存日（W3CDTF）: 2023-05-20
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://www.toukastress.jp/webj/
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/13120786; https://dl.ndl.go.jp/pid/13120786
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 所蔵機関: 国立国会図書館
• 請求記号: Z63-D541
• 関連情報（URI）: https://dl.ndl.go.jp/info:ndljp/pid/13120791
• 関連情報（国立国会図書館永続的識別子）: info:ndljp/pid/13120791; https://dl.ndl.go.jp/info:ndljp/pid/13120791
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 032834824; http://id.ndl.go.jp/bib/032834824
• 整理区分コード: 632

• 要約等: Kuromoji (Lindera umbellata Thunb.) is a deciduous shrub of the camphoraceae family endemic to Japan. It has long been used as an ingredient for tea and essential oil, and its dried trunk branches have been used as an ingredient for medicinal drinks as "Usho," a crude drug with stomachic actions. This paper describes the antiglycative and antiviral activities of a non-volatile extract of kuromoji extract (KE), which we have recently revealed. In absorption and metabolism studies, KE was found to have inhibitory activity against the formation of advanced glycation endproducts (AGEs). AGEs accumulate between collagen fibers in the bone matrix, thus reducing bone strength, and studies using bone glycation samples suggest that KE may ameliorate the reduction in bone strength caused by glycation. Furthermore, an 8-week oral administration of KE to streptozotocin-induced diabetic rats showed that it suppressed renal inflammation in diabetic nephropathy. The antiviral action of KE was confirmed by plaque assay to act against influenza viruses even after infection and to inhibit viral growth. The TCID50 assay showed that KE has antiviral activity against adenovirus and enterovirus, which are viruses that cause colds, as well as new strains of influenza virus and their drug-resistant strains, confirming that the antiviral activity of KE has a wide spectrum of action. A randomized, double-blind, placebo-controlled, parallel-group comparative study on the effects of taking KE-containing candies showed a reduction in the incidence of influenza and in the symptomatic period of cold symptoms. KE is expected to develop as a functional food material unique to Japan in the future because of its various functionalities as described above due to its antiglycative and antiviral effects.
• DOI: 10.24659/gsr.9.4_221
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: Kuromoji (Lindera umbellata Thunb.) is a deciduous shrub of the camphoraceae family endemic to Japan. It has long been used as an ingredient for tea and essential oil, and its dried trunk branches have been used as an ingredient for medicinal drinks as "Usho," a crude drug with stomachic actions. This paper describes the antiglycative and antiviral activities of a non-volatile extract of kuromoji extract (KE), which we have recently revealed. In absorption and metabolism studies, KE was found to have inhibitory activity against the formation of advanced glycation endproducts (AGEs). AGEs accumulate between collagen fibers in the bone matrix, thus reducing bone strength, and studies using bone glycation samples suggest that KE may ameliorate the reduction in bone strength caused by glycation. Furthermore, an 8-week oral administration of KE to streptozotocin-induced diabetic rats showed that it suppressed renal inflammation in diabetic nephropathy. The antiviral action of KE was confirmed by plaque assay to act against influenza viruses even after infection and to inhibit viral growth. The TCID50 assay showed that KE has antiviral activity against adenovirus and enterovirus, which are viruses that cause colds, as well as new strains of influenza virus and their drug-resistant strains, confirming that the antiviral activity of KE has a wide spectrum of action. A randomized, double-blind, placebo-controlled, parallel-group comparative study on the effects of taking KE-containing candies showed a reduction in the incidence of influenza and in the symptomatic period of cold symptoms. KE is expected to develop as a functional food material unique to Japan in the future because of its various functionalities as described above due to its antiglycative and antiviral effects.
• DOI: 10.24659/gsr.9.4_221; https://doi.org/10.24659/gsr.9.4_221
• 関連情報（URI）: http://id.ndl.go.jp/bib/032834824; https://ndlsearch.ndl.go.jp/books/R000000004-I032834824; https://dl.ndl.go.jp/pid/13120791; http://id.ndl.go.jp/digimeta/13120791; https://search.jamas.or.jp/link/ui/2024086131
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 032834824; http://id.ndl.go.jp/bib/032834824; 13120791; http://id.ndl.go.jp/bib/13120791