Antiglycative effect and Antiviral effect of Kuromoji (Lindera umbellata Thunb) extract

• Material Type: 記事
• Title: Antiglycative effect and Antiviral effect of Kuromoji (Lindera umbellata Thunb) extract
• Author/Editor: Akihiko Shimobe; Bunichiro Ashibe; Shigeru Matsumi
• Publication, Distribution, etc.: 日本 : 糖化ストレス研究会
• Publication Date: 2022-12-31
• Publication Date (W3CDTF): 2022-12-31
• Alternative Title: クロモジエキスの抗糖化作用、抗ウイルス作用
• Periodical title: Glycative stress research
• No. or year of volume/issue: 9(4)
• Volume: 9(4)
• ISSN (Periodical Title): 2188-3610
• ISSN-L (Periodical Title): 2188-3610
• Text Language Code: eng; jpn
• DOI: 10.24659/gsr.9.4_221; https://doi.org/10.24659/gsr.9.4_221
• Persistent ID (NDL): info:ndljp/pid/13120791; https://dl.ndl.go.jp/pid/13120791
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Acquisition Basis: オンライン資料収集制度
• Date Accepted (W3CDTF): 2023-12-08T11:19:22+09:00
• Date Captured (W3CDTF): 2023-05-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
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• Periodical Title (URI): https://www.toukastress.jp/webj/
• Periodical Title (Persistent ID (NDL)): info:ndljp/pid/13120786; https://dl.ndl.go.jp/pid/13120786
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Holding library: 国立国会図書館
• Call No.: Z63-D541
• Related Material (URI): https://dl.ndl.go.jp/info:ndljp/pid/13120791
• Related Material (Persistent ID (NDL)): info:ndljp/pid/13120791; https://dl.ndl.go.jp/info:ndljp/pid/13120791
• Data Provider (Database): 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• Bibliographic ID (NDL): 032834824; http://id.ndl.go.jp/bib/032834824
• Bibliographic Record Category (NDL): 632

• Summary, etc.: Kuromoji (Lindera umbellata Thunb.) is a deciduous shrub of the camphoraceae family endemic to Japan. It has long been used as an ingredient for tea and essential oil, and its dried trunk branches have been used as an ingredient for medicinal drinks as "Usho," a crude drug with stomachic actions. This paper describes the antiglycative and antiviral activities of a non-volatile extract of kuromoji extract (KE), which we have recently revealed. In absorption and metabolism studies, KE was found to have inhibitory activity against the formation of advanced glycation endproducts (AGEs). AGEs accumulate between collagen fibers in the bone matrix, thus reducing bone strength, and studies using bone glycation samples suggest that KE may ameliorate the reduction in bone strength caused by glycation. Furthermore, an 8-week oral administration of KE to streptozotocin-induced diabetic rats showed that it suppressed renal inflammation in diabetic nephropathy. The antiviral action of KE was confirmed by plaque assay to act against influenza viruses even after infection and to inhibit viral growth. The TCID50 assay showed that KE has antiviral activity against adenovirus and enterovirus, which are viruses that cause colds, as well as new strains of influenza virus and their drug-resistant strains, confirming that the antiviral activity of KE has a wide spectrum of action. A randomized, double-blind, placebo-controlled, parallel-group comparative study on the effects of taking KE-containing candies showed a reduction in the incidence of influenza and in the symptomatic period of cold symptoms. KE is expected to develop as a functional food material unique to Japan in the future because of its various functionalities as described above due to its antiglycative and antiviral effects.
• DOI: 10.24659/gsr.9.4_221
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• Summary, etc.: Kuromoji (Lindera umbellata Thunb.) is a deciduous shrub of the camphoraceae family endemic to Japan. It has long been used as an ingredient for tea and essential oil, and its dried trunk branches have been used as an ingredient for medicinal drinks as "Usho," a crude drug with stomachic actions. This paper describes the antiglycative and antiviral activities of a non-volatile extract of kuromoji extract (KE), which we have recently revealed. In absorption and metabolism studies, KE was found to have inhibitory activity against the formation of advanced glycation endproducts (AGEs). AGEs accumulate between collagen fibers in the bone matrix, thus reducing bone strength, and studies using bone glycation samples suggest that KE may ameliorate the reduction in bone strength caused by glycation. Furthermore, an 8-week oral administration of KE to streptozotocin-induced diabetic rats showed that it suppressed renal inflammation in diabetic nephropathy. The antiviral action of KE was confirmed by plaque assay to act against influenza viruses even after infection and to inhibit viral growth. The TCID50 assay showed that KE has antiviral activity against adenovirus and enterovirus, which are viruses that cause colds, as well as new strains of influenza virus and their drug-resistant strains, confirming that the antiviral activity of KE has a wide spectrum of action. A randomized, double-blind, placebo-controlled, parallel-group comparative study on the effects of taking KE-containing candies showed a reduction in the incidence of influenza and in the symptomatic period of cold symptoms. KE is expected to develop as a functional food material unique to Japan in the future because of its various functionalities as described above due to its antiglycative and antiviral effects.
• DOI: 10.24659/gsr.9.4_221; https://doi.org/10.24659/gsr.9.4_221
• Related Material (URI): http://id.ndl.go.jp/bib/032834824; https://ndlsearch.ndl.go.jp/books/R000000004-I032834824; https://dl.ndl.go.jp/pid/13120791; http://id.ndl.go.jp/digimeta/13120791; https://search.jamas.or.jp/link/ui/2024086131
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp
• Bibliographic ID (NDL): 032834824; http://id.ndl.go.jp/bib/032834824; 13120791; http://id.ndl.go.jp/bib/13120791