Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period

• 資料種別: 博士論文
• タイトル: Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period
• 著者・編者: Okikawa, Shohei; Kashihara, Hideya; Shimada, Mitsuo; Yoshikawa, Kozo; Tokunaga, Takuya; Nishi, Masaaki; Takasu, Chie; Wada, Yuma; Yoshimoto, Toshiaki
• 著者標目: Okikawa, Shohei; Kashihara, Hideya; Shimada, Mitsuo; Yoshikawa, Kozo; Tokunaga, Takuya; Nishi, Masaaki; Takasu, Chie; Wada, Yuma; Yoshimoto, Toshiaki
• 出版事項: Springer Nature
• 出版年月日等: 2023-02-01
• 出版年（W3CDTF）: 2023-02-01
• 並列タイトル等: 十二指腸空腸バイパスの糖尿病に対する術後早期における効果
• 授与機関名: 徳島大学
• 授与年月日: 2023-10-26
• 授与年月日（W3CDTF）: 2023-10-26
• 報告番号: 甲第3763号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Duodenal-jejunal bypass (DJB); Type2 diabetes mellitus (T2DM); Glucose transporter 1 (GLUT1); sodium-glucose cotransporter 1 (SGLT1); Goto-kakizaki rat
• 対象利用者: 一般
• 一般注記: Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
• 国立国会図書館永続的識別子: info:ndljp/pid/13122542; https://dl.ndl.go.jp/pid/13122542
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2023-12-15T22:13:24+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/118744
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp