Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period

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Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period

Persistent ID (NDL): info:ndljp/pid/13122542

Material type: 博士論文

Author: Okikawa, Shoheiほか

Publisher: Springer Nature

Publication date: 2023-02-01

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of ...

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Material Type: 博士論文
Title: Effect of duodenal‑jejunal bypass on diabetes in the early postoperative period
Author/Editor: Okikawa, Shohei
Kashihara, Hideya
Shimada, Mitsuo
Yoshikawa, Kozo
Tokunaga, Takuya
Nishi, Masaaki
Takasu, Chie
Wada, Yuma
Yoshimoto, Toshiaki
Author Heading: Okikawa, Shohei
Kashihara, Hideya
Shimada, Mitsuo
Yoshikawa, Kozo
Tokunaga, Takuya
Nishi, Masaaki
Takasu, Chie
Wada, Yuma
Yoshimoto, Toshiaki
Publication, Distribution, etc.: Springer Nature
Publication Date: 2023-02-01
Publication Date (W3CDTF): 2023-02-01
Alternative Title: 十二指腸空腸バイパスの糖尿病に対する術後早期における効果
Degree grantor/type: 徳島大学
Date Granted: 2023-10-26
Date Granted (W3CDTF): 2023-10-26
Dissertation Number: 甲第3763号
Degree Type: 博士（医学）
Text Language Code: eng
Subject Heading: Duodenal-jejunal bypass (DJB)
Type2 diabetes mellitus (T2DM)
Glucose transporter 1 (GLUT1)
sodium-glucose cotransporter 1 (SGLT1)
Goto-kakizaki rat
Target Audience: 一般
Note (General): Metabolic surgery is an effective treatment for patients with type 2 diabetes mellitus (T2DM). The aim of this study was to investigate the effect of duodenal-jejunal bypass (DJB) in a rat model of T2DM during the early postoperative period. A rat model of non-obese T2DM was allocated to two groups: a sham group and a DJB group. On postoperative day 1 (1POD), oral glucose tolerance testing (OGTT) was performed and the changes of glucose transporter expressions in the small intestine was evaluated. [18F]-fluorodeoxyglucose ([18]-FDG) uptake was measured in sham- and DJB-operated rats using positron emission tomography-computed tomography (PET-CT). DJB improved the glucose tolerance of the rats on 1POD. The expression of sodium-glucose cotransporter 1 (SGLT1) and glucose transporter 1 (GLUT1) was high, and that of GLUT2 was low in the alimentary limb (AL) of rats in the DJB group. PET-CT showed that [18F]-FDG uptake was high in the proximal jejunum of DJB-operated rats. These results may show that DJB improve glucose tolerance in very early postoperative period as the result of glucose accumulation in the AL because of changes in glucose transporter expression.
Persistent ID (NDL): info:ndljp/pid/13122542
https://dl.ndl.go.jp/pid/13122542
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2023-12-15T22:13:24+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/118744
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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