Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation

• 資料種別: 博士論文
• タイトル: Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation
• 著者・編者: Yamashita, Shoko; Takasu, Chie; Morine, Yuji; Ishibashi, Hiroki; Ikemoto, Tetsuya; Mori, Hiroki; Yamada, Shinichiro; Oya, Takeshi; Tsuneyama, Koichi; Shimada, Mitsuo
• 著者標目: Yamashita, Shoko; Takasu, Chie; Morine, Yuji; Ishibashi, Hiroki; Ikemoto, Tetsuya; Mori, Hiroki; Yamada, Shinichiro; Oya, Takeshi; Tsuneyama, Koichi; Shimada, Mitsuo
• 出版事項: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wiley
• 出版年月日等: 2022-10-19; 30 4
• 出版年（W3CDTF）: 2022-10-19
• 並列タイトル等: インフラマソーム活性化に注目した膵・胆管合流異常の発癌における特徴的な粘膜下変化
• 授与機関名: 徳島大学
• 授与年月日: 2024-01-25
• 授与年月日（W3CDTF）: 2024-01-25
• 報告番号: 甲第3768号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Biliary cancer; activated fibroblast; M2 macrophage; NLRP3; caspase 1
• 対象利用者: 一般
• 一般注記: BackgroundThis study investigated submucosal alterations in biliary carcinogenesis of pancreaticobiliary maljunction (PBM).MethodsThirty-three patients with PBM (including seven with gallbladder [GB] cancer), four with neither biliary tract cancer nor PBM who underwent pancreaticoduodenectomy (controls), and seven with chronic cholecystitis without PBM were enrolled. Protein expression of α-smooth muscle actin (αSMA), CD68, and CD204 in the GB lamina propria and that of NLRP3 and caspase 1 in the GB epithelium and lamina propria were examined.ResultsCompared with the control and cholecystitis groups, αSMA expression was higher in the cancerous part (stroma) of the GB in patients with GB cancer + PBM and in the lamina propria of patients with PBM. The CD204/CD68 ratio in the lamina propria was higher in the PBM group than in the control and cholecystitis groups. NLRP3 and caspase 1 expression in both the lamina propria and epithelium was higher in the PBM than control group. In the PBM group, NLRP3- and caspase 1-positive cells in the lamina propria were located near the epithelium.ConclusionActivated fibroblasts and M2 macrophages in the GB lamina propria may be associated with biliary carcinogenesis of PBM, possibly through inflammasome activation.
• 国立国会図書館永続的識別子: info:ndljp/pid/13587794; https://dl.ndl.go.jp/pid/13587794
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-05-03T22:07:42+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/119056
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp