Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation

• Material Type: 博士論文
• Title: Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation
• Author/Editor: Yamashita, Shoko; Takasu, Chie; Morine, Yuji; Ishibashi, Hiroki; Ikemoto, Tetsuya; Mori, Hiroki; Yamada, Shinichiro; Oya, Takeshi; Tsuneyama, Koichi; Shimada, Mitsuo
• Author Heading: Yamashita, Shoko; Takasu, Chie; Morine, Yuji; Ishibashi, Hiroki; Ikemoto, Tetsuya; Mori, Hiroki; Yamada, Shinichiro; Oya, Takeshi; Tsuneyama, Koichi; Shimada, Mitsuo
• Publication, Distribution, etc.: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wiley
• Publication Date: 2022-10-19; 30 4
• Publication Date (W3CDTF): 2022-10-19
• Alternative Title: インフラマソーム活性化に注目した膵・胆管合流異常の発癌における特徴的な粘膜下変化
• Degree grantor/type: 徳島大学
• Date Granted: 2024-01-25
• Date Granted (W3CDTF): 2024-01-25
• Dissertation Number: 甲第3768号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Biliary cancer; activated fibroblast; M2 macrophage; NLRP3; caspase 1
• Target Audience: 一般
• Note (General): BackgroundThis study investigated submucosal alterations in biliary carcinogenesis of pancreaticobiliary maljunction (PBM).MethodsThirty-three patients with PBM (including seven with gallbladder [GB] cancer), four with neither biliary tract cancer nor PBM who underwent pancreaticoduodenectomy (controls), and seven with chronic cholecystitis without PBM were enrolled. Protein expression of α-smooth muscle actin (αSMA), CD68, and CD204 in the GB lamina propria and that of NLRP3 and caspase 1 in the GB epithelium and lamina propria were examined.ResultsCompared with the control and cholecystitis groups, αSMA expression was higher in the cancerous part (stroma) of the GB in patients with GB cancer + PBM and in the lamina propria of patients with PBM. The CD204/CD68 ratio in the lamina propria was higher in the PBM group than in the control and cholecystitis groups. NLRP3 and caspase 1 expression in both the lamina propria and epithelium was higher in the PBM than control group. In the PBM group, NLRP3- and caspase 1-positive cells in the lamina propria were located near the epithelium.ConclusionActivated fibroblasts and M2 macrophages in the GB lamina propria may be associated with biliary carcinogenesis of PBM, possibly through inflammasome activation.
• Persistent ID (NDL): info:ndljp/pid/13587794; https://dl.ndl.go.jp/pid/13587794
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• Date Accepted (W3CDTF): 2024-05-03T22:07:42+09:00
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/119056
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