Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis

• 資料種別: 博士論文
• タイトル: Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis
• 著者・編者: Miyazaki, Katsuki; Saito, Yu; Ichimura-Shimizu, Mayuko; Imura, Satoru; Ikemoto, Tetsuya; Yamada, Shinichiro; Tokuda, Kazunori; Morine, Yuji; Tsuneyama, Koichi; Shimada, Mitsuo
• 著者標目: Miyazaki, Katsuki; Saito, Yu; Ichimura-Shimizu, Mayuko; Imura, Satoru; Ikemoto, Tetsuya; Yamada, Shinichiro; Tokuda, Kazunori; Morine, Yuji; Tsuneyama, Koichi; Shimada, Mitsuo
• 出版事項: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wiley
• 出版年月日等: 2022-03-24; 29 12
• 出版年（W3CDTF）: 2022-03-24
• 並列タイトル等: X box-binding protein１を介した小胞体ストレス応答不全は非アルコール性脂肪肝炎モデルマウスにおける肝部分切除後の肝再生不良の主要な要因である
• 授与機関名: 徳島大学
• 授与年月日: 2024-03-21
• 授与年月日（W3CDTF）: 2024-03-21
• 報告番号: 甲第3791号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Nonalcoholic steatohepatitis; hepatectomy; liver regeneration; endoplasmic reticulum stress response; lipid droplets
• 対象利用者: 一般
• 一般注記: BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Poor regeneration after hepatectomy in NAFLD is well recognized, but the mechanism is unclear. Endoplasmic reticulum (ER) stress plays an important role in the development of NAFLD. Here, we show that an impaired ER stress response contributes to poor liver regeneration in partially hepatectomized mice.MethodsNon-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH) was induced in mice using our patented feed and 70% partial hepatectomy (PH) was performed. Mice were sacrificed 0, 4, 8, 24, or 48 hours, or 7 days after PH, and liver regeneration and the mRNA expression of ER stress markers were assessed.ResultsNAFLD activity score was calculated as 4–6 points for NAFL and 7 points for NASH. NASH was characterized by inflammation and high ER stress marker expression before PH. After PH, NASH mice showed poorer liver regeneration than controls. High expression of proinflammatory cytokine genes was present in NASH mice 4 hours after PH. Xbp1-s mRNA expression was high in control and NAFL mice after PH, but no higher in NASH mice.ConclusionsDysfunction of the ER stress response might be a cause of poor liver regeneration in NASH.
• 国立国会図書館永続的識別子: info:ndljp/pid/13699596; https://dl.ndl.go.jp/pid/13699596
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-06-07T22:11:38+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/119324
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp