Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis

• Material Type: 博士論文
• Title: Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis
• Author/Editor: Miyazaki, Katsuki; Saito, Yu; Ichimura-Shimizu, Mayuko; Imura, Satoru; Ikemoto, Tetsuya; Yamada, Shinichiro; Tokuda, Kazunori; Morine, Yuji; Tsuneyama, Koichi; Shimada, Mitsuo
• Author Heading: Miyazaki, Katsuki; Saito, Yu; Ichimura-Shimizu, Mayuko; Imura, Satoru; Ikemoto, Tetsuya; Yamada, Shinichiro; Tokuda, Kazunori; Morine, Yuji; Tsuneyama, Koichi; Shimada, Mitsuo
• Publication, Distribution, etc.: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wiley
• Publication Date: 2022-03-24; 29 12
• Publication Date (W3CDTF): 2022-03-24
• Alternative Title: X box-binding protein１を介した小胞体ストレス応答不全は非アルコール性脂肪肝炎モデルマウスにおける肝部分切除後の肝再生不良の主要な要因である
• Degree grantor/type: 徳島大学
• Date Granted: 2024-03-21
• Date Granted (W3CDTF): 2024-03-21
• Dissertation Number: 甲第3791号
• Degree Type: 博士（医学）
• Text Language Code: eng
• Subject Heading: Nonalcoholic steatohepatitis; hepatectomy; liver regeneration; endoplasmic reticulum stress response; lipid droplets
• Target Audience: 一般
• Note (General): BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Poor regeneration after hepatectomy in NAFLD is well recognized, but the mechanism is unclear. Endoplasmic reticulum (ER) stress plays an important role in the development of NAFLD. Here, we show that an impaired ER stress response contributes to poor liver regeneration in partially hepatectomized mice.MethodsNon-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH) was induced in mice using our patented feed and 70% partial hepatectomy (PH) was performed. Mice were sacrificed 0, 4, 8, 24, or 48 hours, or 7 days after PH, and liver regeneration and the mRNA expression of ER stress markers were assessed.ResultsNAFLD activity score was calculated as 4–6 points for NAFL and 7 points for NASH. NASH was characterized by inflammation and high ER stress marker expression before PH. After PH, NASH mice showed poorer liver regeneration than controls. High expression of proinflammatory cytokine genes was present in NASH mice 4 hours after PH. Xbp1-s mRNA expression was high in control and NAFL mice after PH, but no higher in NASH mice.ConclusionsDysfunction of the ER stress response might be a cause of poor liver regeneration in NASH.
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• Date Accepted (W3CDTF): 2024-06-07T22:11:38+09:00
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/119324
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