Muscle-protective effect of carnosine against dexamethasone-induced muscle atrophy in C2C12 myotube

• 資料種別: 博士論文
• タイトル: Muscle-protective effect of carnosine against dexamethasone-induced muscle atrophy in C2C12 myotube
• 著者・編者: Rahman, Md Mizanur; Ulla, Anayt; Moriwaki, Hiroki; Yasukawa, Yusuke; Uchida, Takayuki; Nikawa, Takeshi
• 著者標目: Rahman, Md Mizanur; Ulla, Anayt; Moriwaki, Hiroki; Yasukawa, Yusuke; Uchida, Takayuki; Nikawa, Takeshi
• 出版事項: The Vitamin Society of Japan|Japan Society of Nutrition and Food Science|Center for Academic Publications Japan
• 出版年月日等: 2024-06-30; 70 3
• 出版年（W3CDTF）: 2024-06-30
• 並列タイトル等: C2C12筋管細胞におけるデキサメタゾン誘導性筋萎縮へのカルノシンの筋保護作用; Carnosine mitigates dexamethasone-induced muscle atrophy.
• 授与機関名: 徳島大学
• 授与年月日: 2024-07-31
• 授与年月日（W3CDTF）: 2024-07-31
• 報告番号: 甲第3840号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: carnosine; dexamethasone; muscle atrophy; ubiquitin ligase; C2C12 myotube
• 対象利用者: 一般
• 一般注記: This study investigated the protective effect of carnosine and its components (L-histidine and β-alanine [HA]) against dexamethasone (Dex)-induced muscle atrophy in C2C12 myotubes. Myotubes were treated with Dex (10 μM) to induce muscle atrophy manifested by decreased myotube diameter, low myosin heavy chain content, and increased expression of muscle atrophy–associated ubiquitin ligases (atrogin-1, MuRF-1, and Cbl-b). Carnosine (20 mM) treatment significantly improved the myotube diameter and MyHC protein expression level in Dex-treated C2C12 myotubes. It also downregulated the expression of atrogin-1, MuRF-1, and Cbl-b and suppressed the expression of Forkhead box O (FoxO3a) mediated by Dex. Furthermore, reactive oxygen species production was increased by Dex but was ameliorated by carnosine treatment. However, HA (20 mM), the component of carnosine, treatment was found ineffective in preventing Dex-induced protein damage. Therefore, based on above results it can be suggested that carnosine could be a potential therapeutic agent to prevent Dex-induced muscle atrophy compared to its components HA.
• 国立国会図書館永続的識別子: info:ndljp/pid/13739572; https://dl.ndl.go.jp/pid/13739572
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2024-09-06T22:07:41+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/119544
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp