Muscle-protective effect of carnosine against dexamethasone-induced muscle atrophy in C2C12 myotube

• Material Type: 博士論文
• Title: Muscle-protective effect of carnosine against dexamethasone-induced muscle atrophy in C2C12 myotube
• Author/Editor: Rahman, Md Mizanur; Ulla, Anayt; Moriwaki, Hiroki; Yasukawa, Yusuke; Uchida, Takayuki; Nikawa, Takeshi
• Author Heading: Rahman, Md Mizanur; Ulla, Anayt; Moriwaki, Hiroki; Yasukawa, Yusuke; Uchida, Takayuki; Nikawa, Takeshi
• Publication, Distribution, etc.: The Vitamin Society of Japan|Japan Society of Nutrition and Food Science|Center for Academic Publications Japan
• Publication Date: 2024-06-30; 70 3
• Publication Date (W3CDTF): 2024-06-30
• Alternative Title: C2C12筋管細胞におけるデキサメタゾン誘導性筋萎縮へのカルノシンの筋保護作用; Carnosine mitigates dexamethasone-induced muscle atrophy.
• Degree grantor/type: 徳島大学
• Date Granted: 2024-07-31
• Date Granted (W3CDTF): 2024-07-31
• Dissertation Number: 甲第3840号
• Degree Type: 博士（栄養学）
• Text Language Code: eng
• Subject Heading: carnosine; dexamethasone; muscle atrophy; ubiquitin ligase; C2C12 myotube
• Target Audience: 一般
• Note (General): This study investigated the protective effect of carnosine and its components (L-histidine and β-alanine [HA]) against dexamethasone (Dex)-induced muscle atrophy in C2C12 myotubes. Myotubes were treated with Dex (10 μM) to induce muscle atrophy manifested by decreased myotube diameter, low myosin heavy chain content, and increased expression of muscle atrophy–associated ubiquitin ligases (atrogin-1, MuRF-1, and Cbl-b). Carnosine (20 mM) treatment significantly improved the myotube diameter and MyHC protein expression level in Dex-treated C2C12 myotubes. It also downregulated the expression of atrogin-1, MuRF-1, and Cbl-b and suppressed the expression of Forkhead box O (FoxO3a) mediated by Dex. Furthermore, reactive oxygen species production was increased by Dex but was ameliorated by carnosine treatment. However, HA (20 mM), the component of carnosine, treatment was found ineffective in preventing Dex-induced protein damage. Therefore, based on above results it can be suggested that carnosine could be a potential therapeutic agent to prevent Dex-induced muscle atrophy compared to its components HA.
• Persistent ID (NDL): info:ndljp/pid/13739572; https://dl.ndl.go.jp/pid/13739572
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
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• Date Accepted (W3CDTF): 2024-09-06T22:07:41+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/119544
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