頸部リンパ節転移特異的microRNAの同定-頸部リンパ節転移のモニタリング、予測への応用

• 資料種別: 博士論文
• タイトル: 頸部リンパ節転移特異的microRNAの同定-頸部リンパ節転移のモニタリング、予測への応用
• 著者・編者: 東, 友太郎
• 著者標目: 東, 友太郎
• 出版事項: 鹿児島大学
• 出版年月日等: 2024-01-31
• 出版年（W3CDTF）: 2024-01-31
• 並列タイトル等: Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis
• 授与機関名: 鹿児島大学
• 授与年月日: 2024-01-31
• 授与年月日（W3CDTF）: 2024-01-31
• 報告番号: 甲総研第719号
• 学位: 博士(歯学)
• 本文の言語コード: eng
• 件名標目: oral cancer; oral squamous cell carcinoma; microRNA; biomarker; tumor marker; metastasis; neck lymph node metastasis
• 対象利用者: 一般
• 一般注記: 出版タイプ： VoR; 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; MicroRNAs (miRNAs) have attracted attention as non-invasive cancer biomarkers in various cancers; however, they have not been adequately investigated in oral squamous cell carcinoma (OSCC). This study investigated the diagnostic performance of serum-derived miRNAs at initial diagnosis for primary neck lymph node metastasis and the predictive performance for late neck lymph node metastasis based on long-term (up to approximately 8 years) follow-up of patients with OSCC. The expression of miRNAs in 40 patients with OSCC was quantified using real-time PCR (qPCR), and a comprehensive statistical analysis of the correlation of miRNA expression for primary and late neck lymph node metastases was performed. For the diagnosis of primary neck lymph node metastases, miR-423 and miR-125 were accurate. The miRNA index for primary metastasis diagnosis (miR-PM) calculated by regression analysis showed high diagnostic accuracy. The miR-5100 was useful for predicting late neck lymph node metastases. The miRNA index for late metastasis prediction (miR-LM) calculated using regression analysis showed high prediction accuracy. MiRNAs were useful for diagnosing primary neck lymph node metastases in OSCC and predicting late neck lymph node metastases. It may help to consider individualized treatment, including follow-up, surgical methods, and postoperative management.; Higashi, Yutaro, Kodai Nakamura, Ryota Takaoka, Mika Tani, Yusaku Noma, Kazuki Mori, Kota Yamashiro, Seiya Yokoyama, Tomofumi Hamada, and Tsuyoshi SugiuraIdentification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node MetastasisCancers 2023, 15, 3769.https://doi.org/10.3390/cancers15153769
• 国立国会図書館永続的識別子: info:ndljp/pid/14446031; https://dl.ndl.go.jp/pid/14446031
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2025-08-01T22:07:36+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10232/0002000133
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp