頸部リンパ節転移特異的microRNAの同定-頸部リンパ節転移のモニタリング、予測への応用
Available in National Diet Library
Find on the publisher's website
NDL Digital Collections
Digital data available（鹿児島大学）
Search by Bookstore
Read this material in an accessible format.
Search by Bookstore
Read in Disability Resources
- Other Services
Bibliographic Record
You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.
- Material Type
- 博士論文
- Author/Editor
- 東, 友太郎
- Author Heading
- Publication, Distribution, etc.
- Publication Date
- 2024-01-31
- Publication Date (W3CDTF)
- 2024-01-31
- Alternative Title
- Identification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node Metastasis
- Degree Grantor
- 鹿児島大学
- Date Granted
- 2024-01-31
- Date Granted (W3CDTF)
- 2024-01-31
- Dissertation Number
- 甲総研第719号
- Degree Type
- 博士(歯学)
- Text Language Code
- eng
- Subject Heading
- Target Audience
- 一般
- Note (General)
- 出版タイプ： VoR博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨MicroRNAs (miRNAs) have attracted attention as non-invasive cancer biomarkers in various cancers; however, they have not been adequately investigated in oral squamous cell carcinoma (OSCC). This study investigated the diagnostic performance of serum-derived miRNAs at initial diagnosis for primary neck lymph node metastasis and the predictive performance for late neck lymph node metastasis based on long-term (up to approximately 8 years) follow-up of patients with OSCC. The expression of miRNAs in 40 patients with OSCC was quantified using real-time PCR (qPCR), and a comprehensive statistical analysis of the correlation of miRNA expression for primary and late neck lymph node metastases was performed. For the diagnosis of primary neck lymph node metastases, miR-423 and miR-125 were accurate. The miRNA index for primary metastasis diagnosis (miR-PM) calculated by regression analysis showed high diagnostic accuracy. The miR-5100 was useful for predicting late neck lymph node metastases. The miRNA index for late metastasis prediction (miR-LM) calculated using regression analysis showed high prediction accuracy. MiRNAs were useful for diagnosing primary neck lymph node metastases in OSCC and predicting late neck lymph node metastases. It may help to consider individualized treatment, including follow-up, surgical methods, and postoperative management.Higashi, Yutaro, Kodai Nakamura, Ryota Takaoka, Mika Tani, Yusaku Noma, Kazuki Mori, Kota Yamashiro, Seiya Yokoyama, Tomofumi Hamada, and Tsuyoshi SugiuraIdentification of Neck Lymph Node Metastasis-Specific microRNA—Implication for Use in Monitoring or Prediction of Neck Lymph Node MetastasisCancers 2023, 15, 3769.https://doi.org/10.3390/cancers15153769
- Persistent ID (NDL)
- info:ndljp/pid/14446031
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
- Acquisition Basis
- 博士論文（自動収集）
- Date Accepted (W3CDTF)
- 2025-08-01T22:07:36+09:00
- Format (IMT)
- application/pdf
- Access Restrictions
- 国立国会図書館内限定公開
- Service for the Digitized Contents Transmission Service
- 図書館・個人送信対象外
- Availability of remote photoduplication service
- 可
- Periodical Title (URI)
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション