Memory-phenotype CD4⁺ T lymphocytes : a novel therapeutic target in infectious or autoimmune diseases?

• 資料種別: 記事
• タイトル: Memory-phenotype CD4⁺ T lymphocytes : a novel therapeutic target in infectious or autoimmune diseases?
• 著者・編者: Takeshi Kawabe
• 出版事項: 日本 : Japan Medical Association
• 出版年月日等: 2022-07-15
• 出版年（W3CDTF）: 2022-07-15
• タイトル（掲載誌）: JMA Journal
• 巻号年月日等（掲載誌）: 5(3)
• 掲載巻: 5(3)
• ISSN（掲載誌）: 2433-3298
• ISSN-L（掲載誌）: 2433-328X
• 本文の言語コード: eng
• DOI: 10.31662/jmaj.2022-0048; https://doi.org/10.31662/jmaj.2022-0048
• 国立国会図書館永続的識別子: info:ndljp/pid/14494926; https://dl.ndl.go.jp/pid/14494926
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• 収集根拠: インターネット資料収集保存事業（WARP）
• 受理日（W3CDTF）: 2025-10-21T09:04:40+09:00
• 保存日（W3CDTF）: 2024-09-26
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 遠隔複写可否（NDL）: 不可
• 掲載誌（URI）: https://warp.da.ndl.go.jp/info:ndljp/pid/13747952/www.jmaj.jp/detail.php?id=10.31662%2Fjmaj.2022-0048
• 掲載誌（国立国会図書館永続的識別子）: info:ndljp/pid/14494924; https://dl.ndl.go.jp/pid/14494924
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• 要約等: <p>Infectious diseases are posing threats to the world. Although several types of antibiotics and antivirals have been created to treat the diseases, emerging/re-emerging infectious diseases, as well as those caused by pathogens with multidrug resistance, remain to be significant challenges. As a new therapeutic approach, "host-directed therapy" that enhances immune responses of host cells has been proposed. Nevertheless, the agents used in this strategy often lead to a side effect of hyperinflammation, posing a challenge in developing safe and effective drugs. In this review, I suggest boosting a novel CD4⁺ T lymphocyte population called "memory-phenotype (MP) cells" as a target of the host-directed therapy. MP cells are homeostatically generated from peripheral naïve precursors via recognition of self rather than foreign antigens and are maintained via rapid proliferation in steady state. Surprisingly, MP cells possess innate immune function; they can respond to an inflammatory cytokine IL-12 in the absence of antigen recognition to produce IFN-γ, thereby contributing to host defense against <i>Toxoplasma</i> and <i>Mycobacterium</i>. In this article, I summarize our current understanding of the mechanisms of generation, maintenance, differentiation, and innate effector function of MP CD4⁺ T lymphocytes and further discuss how we can target these cells as a new therapeutic strategy to infectious and autoimmune/inflammatory diseases.</p>
• DOI: 10.31662/jmaj.2022-0048
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: <p>Infectious diseases are posing threats to the world. Although several types of antibiotics and antivirals have been created to treat the diseases, emerging/re-emerging infectious diseases, as well as those caused by pathogens with multidrug resistance, remain to be significant challenges. As a new therapeutic approach, "host-directed therapy" that enhances immune responses of host cells has been proposed. Nevertheless, the agents used in this strategy often lead to a side effect of hyperinflammation, posing a challenge in developing safe and effective drugs. In this review, I suggest boosting a novel CD4⁺ T lymphocyte population called "memory-phenotype (MP) cells" as a target of the host-directed therapy. MP cells are homeostatically generated from peripheral naïve precursors via recognition of self rather than foreign antigens and are maintained via rapid proliferation in steady state. Surprisingly, MP cells possess innate immune function; they can respond to an inflammatory cytokine IL-12 in the absence of antigen recognition to produce IFN-γ, thereby contributing to host defense against <i>Toxoplasma</i> and <i>Mycobacterium</i>. In this article, I summarize our current understanding of the mechanisms of generation, maintenance, differentiation, and innate effector function of MP CD4⁺ T lymphocytes and further discuss how we can target these cells as a new therapeutic strategy to infectious and autoimmune/inflammatory diseases.</p>
• DOI: 10.31662/jmaj.2022-0048; https://doi.org/10.31662/jmaj.2022-0048
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: http://id.ndl.go.jp/digimeta/14494926; https://dl.ndl.go.jp/pid/14494926; https://www.jmaj.jp/download.php?id=10.31662/jmaj.2022-0048; https://search.jamas.or.jp/link/ui/2023252601
• 参照: Homeostasis and immunological function of self-driven memory-phenotype CD4⁺ T lymphocytes; https://cir.nii.ac.jp/crid/1360580229814096128
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; 科学研究費助成事業データベース; https://kaken.nii.ac.jp/ja
• 書誌ID（NDLBibID）: 14494926; http://id.ndl.go.jp/bib/14494926