Memory-phenotype CD4⁺ T lymphocytes : a novel therapeutic target in infectious or autoimmune diseases?
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DOI[10.31662/jmaj.2022-0048]to the data of the same series
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- Material Type
- 記事
- Author/Editor
- Takeshi Kawabe
- Publication, Distribution, etc.
- Publication Date
- 2022-07-15
- Publication Date (W3CDTF)
- 2022-07-15
- Periodical title
- JMA Journal
- No. or year of volume/issue
- 5(3)
- Volume
- 5(3)
- ISSN (Periodical Title)
- 2433-3298
- ISSN-L (Periodical Title)
- 2433-328X
- Text Language Code
- eng
- DOI
- 10.31662/jmaj.2022-0048
- Persistent ID (NDL)
- info:ndljp/pid/14494926
- Collection
- Collection (Materials For Handicapped People:1)
- Collection (particular)
- 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他
- Acquisition Basis
- インターネット資料収集保存事業（WARP）
- Date Accepted (W3CDTF)
- 2025-10-21T09:04:40+09:00
- Date Captured (W3CDTF)
- 2024-09-26
- Format (IMT)
- application/pdf
- Access Restrictions
- インターネット公開
- Availability of remote photoduplication service
- 不可
- Periodical Title (URI)
- Periodical Title (Persistent ID (NDL))
- info:ndljp/pid/14494924
- Data Provider (Database)
- 国立国会図書館 : 国立国会図書館デジタルコレクション
- Summary, etc.
- <p>Infectious diseases are posing threats to the world. Although several types of antibiotics and antivirals have been created to treat the diseases, emerging/re-emerging infectious diseases, as well as those caused by pathogens with multidrug resistance, remain to be significant challenges. As a new therapeutic approach, "host-directed therapy" that enhances immune responses of host cells has been proposed. Nevertheless, the agents used in this strategy often lead to a side effect of hyperinflammation, posing a challenge in developing safe and effective drugs. In this review, I suggest boosting a novel CD4<sup>+</sup> T lymphocyte population called "memory-phenotype (MP) cells" as a target of the host-directed therapy. MP cells are homeostatically generated from peripheral naïve precursors via recognition of self rather than foreign antigens and are maintained via rapid proliferation in steady state. Surprisingly, MP cells possess innate immune function; they can respond to an inflammatory cytokine IL-12 in the absence of antigen recognition to produce IFN-γ, thereby contributing to host defense against <i>Toxoplasma</i> and <i>Mycobacterium</i>. In this article, I summarize our current understanding of the mechanisms of generation, maintenance, differentiation, and innate effector function of MP CD4<sup>+</sup> T lymphocytes and further discuss how we can target these cells as a new therapeutic strategy to infectious and autoimmune/inflammatory diseases.</p>
- DOI
- 10.31662/jmaj.2022-0048
- Access Restrictions
- インターネット公開
- Data Provider (Database)
- 科学技術振興機構 : J-STAGE
- Summary, etc.
- <p>Infectious diseases are posing threats to the world. Although several types of antibiotics and antivirals have been created to treat the diseases, emerging/re-emerging infectious diseases, as well as those caused by pathogens with multidrug resistance, remain to be significant challenges. As a new therapeutic approach, "host-directed therapy" that enhances immune responses of host cells has been proposed. Nevertheless, the agents used in this strategy often lead to a side effect of hyperinflammation, posing a challenge in developing safe and effective drugs. In this review, I suggest boosting a novel CD4<sup>+</sup> T lymphocyte population called "memory-phenotype (MP) cells" as a target of the host-directed therapy. MP cells are homeostatically generated from peripheral naïve precursors via recognition of self rather than foreign antigens and are maintained via rapid proliferation in steady state. Surprisingly, MP cells possess innate immune function; they can respond to an inflammatory cytokine IL-12 in the absence of antigen recognition to produce IFN-γ, thereby contributing to host defense against <i>Toxoplasma</i> and <i>Mycobacterium</i>. In this article, I summarize our current understanding of the mechanisms of generation, maintenance, differentiation, and innate effector function of MP CD4<sup>+</sup> T lymphocytes and further discuss how we can target these cells as a new therapeutic strategy to infectious and autoimmune/inflammatory diseases.</p>
- DOI
- 10.31662/jmaj.2022-0048
- Access Restrictions
- インターネット公開
- Related Material (URI)
- Is Referenced By
- Homeostasis and immunological function of self-driven memory-phenotype CD4<sup>+</sup> T lymphocytes
- Data Provider (Database)
- 国立情報学研究所 : CiNii Research
- Original Data Provider (Database)
- Japan Link Center雑誌記事索引データベースCrossref科学研究費助成事業データベース科学研究費助成事業データベース科学研究費助成事業データベースCrossref
- Bibliographic ID (NDL)
- 14494926