タイトル（掲載誌）Thrombosis and haemostasis
一般注記type:Thesis
Coagulation factor VIII (FVIII) plays an essential role in haemostasis. To date, physiologic activity of FVIII circulating in the bloodstream (S-FVIII) is evaluated by classic coagulation assays. However, the functional relevance of FVIII (-von Willebrand factor complex) immobilised on thrombogenic surfaces (I-FVIII) remains unclear. We used an in vitro perfusion chamber system to evaluate the function of I-FVIII in the process of mural thrombus formation under whole blood flow conditions. In perfusion of either control or synthetic haemophilic blood, the intra-thrombus fibrin generation on platelet surfaces significantly increased as a function of I-FVIII, independent of S-FVIII, under high shear rate conditions. This I-FVIII effect was unvarying regardless of anti-FVIII inhibitor levels in synthetic haemophilic blood. Thus, our results illustrate coagulation potentials of immobilised clotting factors, distinct from those in the bloodstream, under physiologic flow conditions and may give a clue for novel therapeutic approaches for haemophilic patients with anti-FVIII inhibitors.
博士（医学）・甲第602号・平成25年7月22日
The definitive version is available at " http://dx.doi.org/10.1160/TH13-02-0159 "
identifier:Thrombosis and haemostasis Vol.110 No.2 p.316-322
identifier:03406245
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2636
identifier:Thrombosis and haemostasis, 110(2): 316-322
DOIinfo:doi/10.1160/TH13-02-0159
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